Celine Khayat, Presenter: Nothing to Disclose

Julie Mayer, Abstract Co-Author: Nothing to Disclose

Francois Legou MD, Abstract Co-Author: Nothing to Disclose

Fourat Ridouani, Abstract Co-Author: Nothing to Disclose

Thibaud Damy, Abstract Co-Author: Nothing to Disclose

Alain Luciani MD, PhD, Abstract Co-Author: Nothing to Disclose

Hicham Herve Kobeiter MD, Abstract Co-Author: Nothing to Disclose

Alain Rahmouni MD, Abstract Co-Author: Nothing to Disclose

Jean-Francois Deux, Abstract Co-Author: Nothing to Disclose

Evaluate the potential role of T1 and T2 mapping sequences in the diagnosis of acute myocarditis (AM)

15 patients with suspicion of AM and 16 control subjects were included an explored on a 1.5T MR. Pre contrast T1 and T2 shortened modified look-locker inversion recovery and STIR T2 sequences were acquired in a mid ventricular short-axis (SA) section and in the four-chamber (4C) section. Cine SSFP, first pass and LGE sequences were also acquired. Mean myocardial T1, T2 and STIR T2 signal intensity (SI) were calculated from manual contouring of the short axis section. The same parameters were measured independently for lateral and interventricular septum (IVS), both on the SA and the 4C sections. Number and location of positive segments were noticed on LGE sequence. A non parametric test was used to compare data.

Mean number of involved segments on LGE was 5±1.5 with a systematic involvement of mild lateral left ventricular wall in patients. Mean myocardial T1, T2 and STIR T2 SI were in the same range (P=NS) between patients (998±52 ms, 53.0±5 ms and 173±42, respectively) and subjects (969±47 ms, 50.8±4 ms and 173±47, respectively). Myocardial T1 and T2 of patients were significantly (P<0.05) higher in the lateral wall, on the SA section (1016 ± 58 and 54 ± 8 ms, respectively for T1 and T2) and on the 4C section (1023 ± 65 and 54 ± 6 ms, respectively for T1 and T2), in comparison to control subjects (957 ± 45 and 49 ± 3 ms respectively for T1 and T2 on the SA section, and 937 ± 43 and 49 ± 3ms respectively for T1 and T2 on the 4C section). STIR T2 SI in the lateral wall was in the same range (P=0.3) between patients and control subjects: 176 ± 50 vs. 148 ± 48 on the SA section and 170 ± 59 vs. 159 ±43 on the 4C section, respectively for patients and control subjects. T1, T2 and STIR T2 SI of the IVS were in the same range between patients and subjects (data not shown).

T1 and T2 were increased in the lateral wall in case of AM in comparison to control subject. T2 mapping seems to be more efficient than STIR T2 sequence for detection of local edema in the lateral wall.

Pre contrast mapping sequences can detect myocardial lesions of AM and could increase diagnostic accuracy of this disease, especially in case of contraindication to contrast medium injection

Khayat, C, Mayer, J, Legou, F, Ridouani, F, Damy, T, Luciani, A, Kobeiter, H, Rahmouni, A, Deux, J, Potential Role of T1 and T2 Mapping Sequences in the Diagnosis of Acute Myocarditis.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013778.html