Jonas Christoph Apitzsch MD, Presenter: Nothing to Disclose

Dirk Robert Albanus, Abstract Co-Author: Nothing to Disclose

Z. Erdem, Abstract Co-Author: Nothing to Disclose

Oktay Erdem MD, Abstract Co-Author: Nothing to Disclose

Anton Frederik Verburg, Abstract Co-Author: Nothing to Disclose

Florian F. Behrendt MD, Abstract Co-Author: Nothing to Disclose

Felix Mottaghy MD, PhD, Abstract Co-Author: Nothing to Disclose

Alexander Heinzel, Abstract Co-Author: Nothing to Disclose

To retrospectively compare the performance of combined 68Ga-DOTA-TATE PET/CT and stand-alone ceCT in 54 patients with NET

Patients with histologically confirmed NET and available follow-up of at least 6 months (median 12.6 months; range 6.1–23.2) were included. PET/CT and ceCT images were analyzed separately by two blinded nuclear medicine physicians and two radiologists, respectively. Finally all investigators reviewed all detected lesion together reaching a consensus-grading for PET/CT. The results were then compared to the reference standard consisting of clinical follow-up data

Regarding true positive lesions, PET/CT detected: 139 bone-lesions vs. 48 (ceCT), 106 lymph node metastases (PET/CT) vs. 71 (CT) and 26 lung lesions (PET/CT and CT each). On a patient basis, PET/CT achieved a higher sensitivity (100% vs. 47%) and specificity (89% vs. 49%) for bones than stand-alone ceCT. For lymph nodes the effect was similar (sensitivity 92% vs. 64% and specificity 83% vs. 59%). For the detection of pulmonary lesions the sensitivity was identical (100%) while specificity of PET/CT was superior to CT-alone (95% vs. 82%)

In summary, the use of Gallium-68-DOTATATE-PET-CT appears to lead to an increase in sensitivity and specificity for the detection of extra-hepatic NET metastases compared to stand-alone ceCT

use of 68Ga-DOTATATE PET/CT appears to lead to an increase in quality for the detection of extra-hepatic NET metastases compared to stand-alone ceCT

Apitzsch, J, Albanus, D, Erdem, Z, Erdem, O, Verburg, A, Behrendt, F, Mottaghy, F, Heinzel, A, 68Ga-DOTATATE-PET/CT vs. Stand-alone Contrast Enhanced CT for the Detection of Extra-hepatic Metastases in Patients with Neuroendocrine Tumors (NET).  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013754.html