Xianfu Luo, Presenter: Nothing to Disclose

Fuhua Yan, Abstract Co-Author: Nothing to Disclose

Wei-Min Chai, Abstract Co-Author: Nothing to Disclose

Huan Zhang, Abstract Co-Author: Nothing to Disclose

Huanhuan Liu, Abstract Co-Author: Nothing to Disclose

Xiao Zhu Lin MD, Abstract Co-Author: Nothing to Disclose

To assess the accuracy of combined multiple short echo of gradient echo (CMSGRE) imaging for noninvasive quantification severe iron accumulation in the liver.

Forty-two patients with elevated ferritin and suspected of iron overload were included in our study. MR was then performed for liver iron quantification on 1.5T GE Healthcare Signa Twin speed systems. First, a routine multiple gradient echo (RMGRE) imaging was acquired 10 echoes in a sequence with first echo time (TE) of 1.5ms and an echo spacing of 1.2ms. And then a group of combined multiple short echo of gradient echo (CMSGRE) technique was used in 10 separately sequence with the first TE of 1ms and an echo spacing of 0.2ms. The gradient echo sequences were run all with repetition time (TR) of 50ms, a flip angle of 20°and a readout bandwidth of 83.3 kHz. Frequency fat suppression was used for each single sequence. R2* of the liver was calculated with the functool of R2* on ADW4.3 workstation. 3 parameter fitting model was used to calculate R2*. Two radiologists measured R2* with three region of interest (ROI) for each patient. The accuracy of two group for R2* quantification was judged by curve fitting analysis. R Square and residual sum of squares of regressions from two groups were compared in severe iron accumulation patients (R2*>585Hz).

For all 42 patients the R2* was 335.47± 58.34Hz and ranged from 34.13Hz to 1503.10Hz. 11 of 42 patients with chronic liver disease had normal R2* liver.10 patients were with severe iron accumulation (R2*>585Hz). The R2* of sever iron accumulation patients was 1035.36±101.99 Hz ranged from 665.91Hz to 1721.87Hz determined by CMSGRE. The R Square of CMSGRE and RMGRE was 0.98 and 0.39 respectively. And the residual sum of squares for CMSGRE and RGRE was 0.04 and 71.39, respectively. CMSGRE was more accurate than SMGRE in quantification of severe iron accumulation in the liver(P＜0.001).

Combined multiple short echo of gradient echo imaging will give more accuracy for quantification of liver iron concentrate in severe iron accumulation patients.

With combined multiple short echo of gradient echo imaging for quantification graveness iron accumulation, MRI might provide more accuracy information for chelation therapy in the clinical practice in the future.

Luo, X, Yan, F, Chai, W, Zhang, H, Liu, H, Lin, X, Combined Multiple Short Echo of Gradient Echo (CMSGRE) Imaging for Accurate Measurement of Severe Iron Accumulation in the Liver.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013526.html