Baoying Chen, Presenter: Nothing to Disclose

GUANGBIN CUI, Abstract Co-Author: Nothing to Disclose

Zhuo Xie, Abstract Co-Author: Nothing to Disclose

linfeng yan, Abstract Co-Author: Nothing to Disclose

yuchuan hu, Abstract Co-Author: Nothing to Disclose

To show the diagnostic value of bi-exponential ADC based on IVIM with multiple b-value DWI in benign and malignant breast lesions, in comparison to the conventional mono-exponential apparent diffusion coefficient (ADC) with single b-factor DWI. 

32 patients diagnosed with 20 malignant and 15 benign breast lesions were enrolled in the study. Consent form has been obtained prior to the study. Patients underwent DWI at 3.0T with single b-factor range (b=0, 1000 s/mm2) and multiple b-factor range (b=0, 25, 50, 75, 100, 300, 500, 800, 1000, 1200, 2000, 3000 s/mm2). 32 contralateral normal healthy glandular tissues from the same cohort were considered as control. ADC (b=0 and 1000 s/mm2) and IVIM parameters (tissue diffusivity D, pseudo-diffusion coefficient D*, perfusion fraction f) were calculated respectively based on mono-exponential and bi-exponential analysis. The data were compared in between malignant, benign lesions and normal healthy glandular tissues. The diagnostic efficiency of these parameters was evaluated by ROC curve and area under the ROC curve (AUC).

It was found out that ADC and D values of malignant group were significant lower than those of benign group and control group (P<0.05). There were significant differences between benign and malignant group, benign and control group, malignant and control group in value of f (P<0.01, P<0.05, P<0.01 respectively). Importantly, the f value of malignant tumors was significantly higher than that of benign lesions especially in the b-factor range of 0-800 s/mm2 (P = 0.000).D* value was not significantly different between benign and malignant group in the b-factor range of 800-3000 s/mm2. The diagnostic sensitivity of D, ADC, f, D* decreased progressively. D and ADC values showed higher specificity than f, D*. The combination of D and f represented higher sensitivity and specificity.

Quantitative IVIM parameters provide separate information of fast and slow diffusion component by bi-exponential decay model. They can be used in differential diagnosis of benign and malignant lesions.

Multi-b-value DWI has been most simply performed, and IVIM can separately estimate tissue perfusion and diffusivity. Although some questions are remained to be clarified, multi-b-value DWI and IVIM will certainly be of great help for the diagnosis of breast lesions.

Chen, B, CUI, G, Xie, Z, yan, l, hu, y, Investigate the Value of Multiple B-Value Diffusion-Weighted Imaging based on Intravoxel Incoherent Motion (IVIM) in Differentiating Benign and Malignant Breast Lesions.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013521.html