Hirofumi Koike, Presenter: Nothing to Disclose

Eijun Sueyoshi MD, Abstract Co-Author: Nothing to Disclose

Ichiro Sakamoto, Abstract Co-Author: Nothing to Disclose

Masataka Uetani MD, Abstract Co-Author: Nothing to Disclose

Recently, software programs that quantify and objectively evaluate lung perfusion blood volume (PBV) using dual-energy CT have been developed. The present  study evaluates the quantification of lung PBV using Syngo software in patients with and without pulmonary hypertension.

Two hundred sixty three patients who underwent echocardiography in the previous month underwent dual-energy CT angiography. The population consisted of 2 patient groups with and without pulmonary hyperension (n=52 and n=211). We evaluated lung PBV quantified with using Syngo software, associations between lung PBV and pulmonary artery pressure, and the impact of lung PBV on pulmonary hypertension pathogenesis.

Early phase lung PBV values were 24.7±1.3 and 29.0±0.6 in patients with and without pulmonary hypertension, with a significance difference observed between the two study group (p<0.0032). Late phase values were13.9±0.6 and 14.6±0.4, with no significant difference observed between patiens with and without pulmonary hypertesion (p=0.47). In the early phase, a negative correlation between lung PBV value and pulmonary artery pressure was observed (R=-0.41, p<0.0001). In patients with pulmonary hypertension secondary to pulmonary disease and embolism, lung PBV values were 19.3±2.0 and 24.7±2.2. they were lower in comparison with those in patients without pulmonary hypertension.

Quantification of lung PBV reflects reduced pulmonary perfusion in patients with pulmonary hypertension. This technique may prove useful for objective evaluation of pulmonary blood flow in patients with pulmonary hypertension. 

This method objectively showed the reduced pulmonary perfusion in patients with pulmonary hypertension. This method may be a new diagnostic tool for the evaluation of pulmonary hypertension.

Koike, H, Sueyoshi, E, Sakamoto, I, Uetani, M, Quantification of Lung Perfusion Blood Volume (Lung PBV) by Dual-energy CT in Patients with and without Pulmonary Hypertension.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013258.html