Yanwei Miao, Presenter: Nothing to Disclose

Rui Hu MS, Abstract Co-Author: Nothing to Disclose

Wei-Wei Wang MD, PhD, Abstract Co-Author: Nothing to Disclose

Bingbing Gao, Abstract Co-Author: Nothing to Disclose

shiyun tian, Abstract Co-Author: Nothing to Disclose

Minting Zheng, Abstract Co-Author: Nothing to Disclose

He Qing Wang MSc, Abstract Co-Author: Nothing to Disclose

As a kind of degeneration diseases, Alzheimer’s disease (AD) progressively involves into the different brain regions in turn. The measurement of brain region volume is up to date a structure biomarker for AD, but it is not used widely based on inconvenient process. This study is to exploit the ability of diffusion kurtosis imaging (DKI) on the detection of brain structure vulnerability in AD.

Twenty three cases of clinically confirmed AD and Twenty four age- and sex-matched healthy volunteers underwent conventional MRI scan and DKI scanning on a 3.0T MR imaging scanner. The bilateral MK values, Ka values, Kr values, MD values, Da values, Dr values and FA values of the frontal WM, parietal WM, occipital WM, temporal WM, hippocampus, thalamus, splenium of the corpus callosum, genu of the corpus callosum, trunk of the corpus callosum, anterior limb of the internal capsule, posterior limb of the internal capsule, external capsule, and hemispherium cerebelli were measured manually by two neuroradiologist respectively. Two independent samples t-test was used to compare the mean values of parameters in all brain regions between the AD and healthy groups. Receiver operating characteristic (ROC) test were used to assess the ability of regional diffusion measures to discriminate differences between groups.

There is the high consistency of all DKI data between the two measurers (ICC=0.96). The significant different mean value of MK, Ka, Kr, MD, Da, Dr and FA value were present between AD group and healthy group in all regions, especially in the parietal WM, temporal WM and hippocampus( P＜0.05). From ROC analysis, the biggest area under ROC curve (AUC) value of 0.954 belongs to Dr value (0.758) as the cutoff for diagnosing AD in the temporal WM, In turn, the AUC of 0.880, 0.823 and 0.804 was attributed to the Dr value in hippocampus, the MD value in temporal WM and the Dr value in parietal WM.  

The temporal WM, hippocampus and parietal WM are the vulnerable brain structures assessed by using DKI parameters.

DKI can quantitatively evaluate microstructure damage in AD patients.

Miao, Y, Hu, R, Wang, W, Gao, B, tian, s, Zheng, M, Wang, H, Is Diffusion Kurtosis a New Biomarker to Assess the Vulnerable Brain Structure in Alzheimer's Disease?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013247.html