Yoon Seong Choi MD, Abstract Co-Author: Nothing to Disclose

Jinna Kim MD, Abstract Co-Author: Nothing to Disclose

Mina Park MD, Abstract Co-Author: Nothing to Disclose

Sung Jun Ahn MD, Abstract Co-Author: Nothing to Disclose

Seung-Koo Lee MD, PhD, Presenter: Nothing to Disclose

The purpose of this study was to investigate the differences in dynamic contrast-enhanced MR imaging (DCE-MRI) parameters according to the status of human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) biomarker in oropharyngeal squamous cell carcinoma (SCC) by histogram analysis.

DCE-MRI was performed in a total of 21 consecutive patients with pathologically confirmed oropharyngeal SCC, and parameter maps composed of Ktrans (microvascular permeability), Ve (extravascular-extracellular space volume), and Vp (plasma volume) were obtained. Enhancing tumors were manually segmented on each slice of parameter maps to contain the entire tumor volume. The histogram parameters consisting of 25th, 50th, 75th percentile, mean value, skewness, and kurtosis of the DCE-MRI parameters were calculated and compared between the subgroups based on HPV and EGFR biomarker status using Wilcoxon rank-sum test.

From the histogram analysis of Ktrans maps, mean Ktrans value were significantly lower (P = 0.036) and positively skewed in EGFR overexpression group. And mean Ktrans value was higher in HPV-positive group without significant difference (P = 0.164). Other DCE parameters, Ve and Vp, were not significantly different between the subgroups.

Our preliminary evidence using histogram analysis of DCE-MRI parameters (Ktrans) based on whole tumor volume suggests that it may be useful to assess tumor microenvironment associated with molecular biomarkers in oropharayngeal SCC.

Histogram analysis of Ktrans value may be a noninvasive imaging-based parameter that can be used to evaluate biomarker profiles in oropharyngeal SCC.

Choi, Y, Kim, J, Park, M, Ahn, S, Lee, S, Human Papillomavirus and Epidermal Growth Factor Receptor in Oropharyngeal Squamous Cell Carcinoma: Application of Dynamic Contrast Enhanced MR Imaging by Histogram Analysis.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013141.html