Yoshitaka Goto MD, Presenter: Nothing to Disclose

Masaki Ishida MD,PhD, Abstract Co-Author: Nothing to Disclose

Shinichi Takase, Abstract Co-Author: Nothing to Disclose

Mio Uno MD, Abstract Co-Author: Nothing to Disclose

Motonori Nagata MD, PhD, Abstract Co-Author: Nothing to Disclose

Yasutaka Ichikawa MD, Abstract Co-Author: Nothing to Disclose

Kakuya Kitagawa MD, PhD, Abstract Co-Author: Nothing to Disclose

Hajime Sakuma MD, Abstract Co-Author: Research Grant, Siemens AG Research Grant, Koninklijke Philips NV Research Grant, General Electric Company Research Grant, Bayer AG Research Grant, Guerbet SA

Displacement encoding with stimulated echoes (DENSE) MRI can provide accurate quantification of myocardial strain based on displacement of myocardial tissue. The drawback of DENSE MRI is the necessity of acquiring additional image dataset in CMR study. Feature Tracking (FT) technique recently emerged as a method to quantify myocardial strain by analyzing standard cine MR images. However, accuracy of global and regional myocardial strain measured by FT has not been well established. The purpose of this study was to compare myocardial strain by FT to those derived from DENSE in patients with acute myocardial infarction (AMI).

Twenty patients (65±13 years) with AMI underwent steady state free precession cine MRI, DENSE MRI and late gadolinium enhancement MRI on a 1.5 T MR system. Left ventricular strain maps were generated by FT analysis (cmr42) of cine MRI as well as DENSE MRI on matched 3 short-axis planes of left ventricle (basal, mid, apical). Each short axis slice was divided into 6 equal circumferential sectors. FT-derived circumferential strain was compared with that determined by DENSE MRI by adjusting cardiac phase for global and segmental level. Regional circumferential strain was compared between infarct and remote normal segments.

Global circumferential strain determined by FT showed a good agreement with that by DENSE MRI (Pearson’s correlation coefficient 0.85, p<0.0001; bias 0.02, limits of agreement −0.03 to 0.06; coefficient of variability 16%; intra-class correlation coefficient 0.68). For segmental circumferential strain, Pearson’s correlation coefficient between FT and DENSE approaches was 0.61 (p<0.0001) with bias and limits of agreement of 0.02 and −0.07 to 0.11, coefficient of variability of 33% and intra-class correlation coefficient of 0.55. Regional circumferential strain determined by FT in infarct segments (-0.08 ± 0.05) was significantly altered when compared with that in remote normal segments (-0.15 ± 0.05, p<0.0001).

FT measurement of global circumferential strain demonstrated good agreement with DENSE MRI measurement. FT technique allows for accurate assessment of altered regional strain in patients whit AMI.

Feature tracking technique allows for the accurate assessment of circumferential strain in patients with acute myocardial infarction without increasing CMR examination time.

Goto, Y, Ishida, M, Takase, S, Uno, M, Nagata, M, Ichikawa, Y, Kitagawa, K, Sakuma, H, Comparison of Cine MRI feature Tracking and Displacement Encoding with Stimulated Echoes MRI for the Assessment of Global and Segmental Left Ventricular Strain in Patients with Acute Myocardial Infarction.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013095.html