Julie Celine Dutoit MD, Presenter: Nothing to Disclose

Matthias Vanderkerken, Abstract Co-Author: Nothing to Disclose

Anne-Sophie Beerens MD, MA, Abstract Co-Author: Nothing to Disclose

Koenraad L. Verstraete MD, PhD, Abstract Co-Author: Nothing to Disclose

1. How to perform whole body, dynamic contrast-enhanced and diffusion weighted MRI in patients with multiple myeloma or its prestages. 2. How to evaluate the anatomical and functional images to assess total tumor load and response to treatment. 3. How to recognize common pitfalls and mimics.

MR imaging is the most sensitive technique for the detection of bone marrow pathologies such as multiple myeloma (MM) or its prestages monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM). Part 1: Technical aspects. Imaging consists of coronal T1-weighted and STIR T2-weighted images of the whole body, sagittal T1-weighted and fat-suppressed T2-weighted images of the spine, multislice dynamic contrast enhanced MRI with time-intensity curves and diffusion weighted b-images (0-1000) with ADC calculation of the thoracolumbar spine. Part 2: Evaluation. How can a combined 'skeletal score' be obtained based on the pattern and extent of bone marrow invasion, the type of TIC and enhancement rate, and data from diffusion weighted imaging. This approach allows differentiation between MGUS, SMM, MM and assessment of response to treatment. Part 3: Displays several mimics and pitfalls (e.g. vertebral fractures, intracorporal disc herniation, red bone marrow hyperplasia, ...)

http://abstract.rsna.org/uploads/2014/14012671/14012671_k46m.pdf

Dutoit, J, Vanderkerken, M, Beerens, A, Verstraete, K, How to Perform and Evaluate Whole Body, Dynamic Contrast-enhanced and Diffusion MR Imaging in Multiple Myeloma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14012671.html