Chen-Pin Chou MD, Presenter: Research funded, Hologic, Inc

Chia-Ling Chiang MD, Abstract Co-Author: Nothing to Disclose

Wei-Teng Wang, Abstract Co-Author: Nothing to Disclose

To compare the diagnostic accuracy of contrast-enhanced breast tomosynthesis (CEBT) and dynamic contrast-enhanced breast MRI (DCE-MRI) for breast lesions detected on digital mammogram.

Institutional review board approved the study. Written informed consent was obtained from all patients. A total of 212 consecutive women suspected of having breast lesions on digital mammogram between March 2012 and April 2014 were enrolled in this study. All women had both CEBT and DCE-MRI before biopsy. For the dual-energy CEBT, a modified Selenia Dimensions (Hologic, Inc.) machine was used. Simultaneously 2D mammogram and 3D tomosynthesis were taken after injection with 1.5 mL iodine contrast agent per kilogram of body weight of and imaged between 2 and 6 minutes after injection. Contrast-enhanced images were taken in the suspicious breast (pre-contrast MLO view, post-contrast CC and MLO view) and contralateral breast (post-contrast MLO view). The BI-RADS classifications on CEBT were finally determined based on findings on combinations of 2D mammogram, 3D tomosynthesis and post-contrast subtraction 2D and 3D images. Women were also evaluated at 1.5T (GE) or 3T MRI (Siemens) with dedicated breast coil. Different radiologists interpreted CEBT and DCE-MRI.

Total 259 histological findings were available in 212 women (mean age 51.3 years, range 31-70 years). About 79% women did not have clinical symptoms. 31 women had at least two breast lesions in unilateral breasts. 8 women had bilateral breast lesions. The most common findings of lesions was microcalcification (60%). The pathology revealed 167 benign lesions and 92 breast malignancies (52 carcinoma in situ, and 40 invasive breast cancers). The sensitivity/ specificity of CEBT and DCE-MRI for diagnosing breast cancers were 93%/53% and 86%/74%, respectively.

CEBT and DCE-MRI showed similar diagnostic performance for abnormal lesions on mammogram.

CEBT is an flexible imaging tool for women who cannot undergo breast MRI for various reasons,

Chou, C, Chiang, C, Wang, W, Diagnostic Accuracy of Contrast-enhanced Breast Tomosynthesis and Dynamic Contrast-enhanced Breast MRI.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14012582.html