Tashfeen Ekram MD, Presenter: Nothing to Disclose

Shreyas Shreenivas Vasanawala MD, PhD, Abstract Co-Author: Research collaboration, General Electric Company Stockholder, Morpheus Imaging, Inc

Marcus T. Alley PhD, Abstract Co-Author: Nothing to Disclose

Frandics Pak Chan MD, PhD, Abstract Co-Author: Nothing to Disclose

Beverley Mansfield Newman MD, MBBCh, Abstract Co-Author: Nothing to Disclose

Albert Hsiao MD, PhD, Abstract Co-Author: Founder, Morpheus Imaging, Inc Consultant, Morpheus Imaging, Inc

Conventional, planar phase-contrast (2D-PC) imaging is the gold standard for non-invasive measurement of blood flow, routinely used in the assessment of structural heart disease by MRI. Nevertheless, at many institutions, nuclear perfusion scintigraphy (NPS) remains necessary for confirmation of differential pulmonary perfusion, but requires an additional exam with radiation exposure, and in younger children, prolongs cardiac anesthesia. Highly-accelerated 4D phase-contrast (4D-PC) MRI is an evolving technology that has potential to greatly simplify the congenital heart MRI examination. We hypothesized that 4D-PC may be sufficient for quantification of differential pulmonary flow.

With IRB approval and HIPAA-compliance, we retrospectively identified patients who underwent NPS as well as a cardiac MRI with 4D-PC from October 2011 through February 2014 without major surgery between exams. A total of 26 4D-PC examinations from 25 patients (15 male, 10 female) were identified. Aortic, main and branch pulmonary flow were quantified from 4D-PC. Pearson correlation and Bland-Altman analysis were used to analyze the quantitative consistency of 4D-PC data. The same analyses were then applied to compare differential pulmonary perfusion from 4D-PC against 2D-PC and NPS.

There was strong consistency between aortic flow and pulmonary flow measurements obtained at the pulmonary valve or as the sum of the branch pulmonary arteries (ρ=0.93, 0.90). Differential pulmonary flow measurements obtained from 4D-PC and NPS largely agreed (ρ=0.92), while correlation between 2D-PC and NPS was more modest (ρ=0.74). MRI and NPS were better matched among patients without substantial pulmonary regurgitation (RF<20%, n=15) whether obtained by 4D-PC (ρ=0.97) or 2D-PC (ρ=0.94). In contrast, the presence of substantial pulmonary regurgitation (RF≥20%, n=11) more severely impacted the accuracy of 2D-PC (ρ=0.47) than 4D-PC (ρ=0.89).

Highly-accelerated 4D-PC may not only help simplify congenital cardiac MRI, but may obviate the need for a separate nuclear scintigraphic examination to confirm differential pulmonary perfusion.

The use of highly-accelerated 4D-PC as part of a congenital cardiac MRI may obviate the need for a separate nuclear scintigraphic examination to quantify differential pulmonary perfusion.

Ekram, T, Vasanawala, S, Alley, M, Chan, F, Newman, B, Hsiao, A, Improved Differential Pulmonary Perfusion Measurement with Highly-accelerated 4D-PC MRI.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14012534.html