Osmar Cassio Saito MD, PhD, Presenter: Nothing to Disclose

Maria Cristina Chammas MD, Abstract Co-Author: Nothing to Disclose

Maria Teresa Bonanomi PhD, MD, Abstract Co-Author: Nothing to Disclose

Giovanni Guido Cerri MD, PhD, Abstract Co-Author: Nothing to Disclose

(1) We intend to review the retinoblastoma main findings by means of ultrasound and MRI; (2) to compare imaging findings (ultrasound and MRI) and anatomopathological findings after enucleation; (3) to evaluate which method can detect best the optical nerve invasion.

(1) 18 monocular retinoblastoma tumors were evaluated by means of ultrasound with color Doppler and MRI at Clinicas Hospital of University of São Paulo (2) The mean age were 24 month year old (3) All patients underwent ultrasound examination with 16 MHz probe Toshiba applio 500 GE MRI 1,5 tesla (4) All patiens underwent general anaesthesia before MRI and Ultrasound (5) Color Doppler evaluated the arterial systolic velocity and vein velocity inside optic nerve in the normal and tumor eye; (6) We also calculated IP and RI in the central retina artery and vein; (7) All tumors were evaluated by T1, T2 with gadolinium injection.

(1) All 18 patients had monocular retinoblastoma were enucleated and anatomopathogical study were made in order to detect optic nerve invasion; (2) 11 patients had optic nerve invasion (61%); (3) 4 patients had optic nerve invasion detected by MRI (retrobulbar enhancement and optic nerve thickening (36 %); (4) 9 had increased velocity vein (81%); (5) Central retina arterial velocity and central retina vein velocity were higher in tumor than in normal eyes (p<0.001 on both); (6) the larger tumor volume, the higher was central retina vein velocity (p=0.03).

(1) Retinoblastoma eyes have faster flow; (2) Lower PI is related to nerve optic invasion.

Retinoblastoma is a highly malignant ocular neoplasm that shows a tendency to optic nerve invasion which implies in a poorer prognosis for the patient. The diagnosis of nerve invasion at presentation is important for prognostic and management. Retinoblastoma invasion of the optic nerve may not be detected by MRI. Due to the scant space inside lamina cribrosa to harbor artery, vein and tumor cells, it seems logical to study blood flow in retinoblastoma, aiming to detect nerve invasion.

Saito, O, Chammas, M, Bonanomi, M, Cerri, G, Retinoblastoma Nerve Optic Invasion: How Color Doppler Can Improve Diagnosis Better than MRI.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14012348.html