Hossein Nejadnik MD, PhD, Presenter: Nothing to Disclose

Fanny Chapelin MS, Abstract Co-Author: Nothing to Disclose

olga lenkov BSC, Abstract Co-Author: Nothing to Disclose

Heike E. Daldrup-Link MD, Abstract Co-Author: Nothing to Disclose

Stem cell-therapies and other cell therapies have become a powerful new tool for tissue regeneration. The field is expanding and rapidly entering clinical applications, with currently over 4000 ongoing clinical stem cell trials worldwide. Imaging technologies need to diagnose stem cell delivery and engraftment at the target site and provide information about viability, differentiation and tumorigenic potential of the cells. Our group and others established immediately clinically applicable stem cell labeling and tracking methods with magnetic resonance (MR) contrast agents, which combine approaches for radiation free cell tracking with the high soft tissue contrast and high spatial resolution of MRI. This exhibition will demonstrate basic cell handling technologies for radiologists, explain various labeling methods, discuss safety considerations, and show examples of stem cell tracking with commercially available, FDA approved iron nanoparticles and gadolinium chelates

1) Explain cell culture techniques, relevant for Radiologists 2) Review previous and currently available MR contrast agents for cell labeling 3) Elaborate labeling methods 4) Discuss safety considerations for stem cell labeling 5) Provide examples of studies using labeled stem cells in vitro and in vivo 6) Explain prospective clinical applications

http://abstract.rsna.org/uploads/2014/14011775/14011775_3wqg.pdf

Nejadnik, H, Chapelin, F, lenkov, o, Daldrup-Link, H, Stem Cell Tracking with Clinically Applicable MR Contrast Agents.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011775.html