Ulrich Grosse MD, Abstract Co-Author: Nothing to Disclose

Juergen Hetzel, Abstract Co-Author: Nothing to Disclose

Lutz Guendel, Abstract Co-Author: Employee, Siemens AG

Sergios Gatidis MD, Abstract Co-Author: Nothing to Disclose

roland syha, Abstract Co-Author: Nothing to Disclose

Christoph Schabel MD, Abstract Co-Author: Speaker, Siemens AG

Fabian Springer MD, Abstract Co-Author: Nothing to Disclose

Claus Detlef Claussen MD, Abstract Co-Author: Nothing to Disclose

Konstantin Nikolaou MD, Abstract Co-Author: Speakers Bureau, Siemens AG Speakers Bureau, Bracco Group Speakers Bureau, Bayer AG

Marius Horger MD, Presenter: Nothing to Disclose

To objectify changes in volume and density of treated and untreated pulmonary lobes following endobronchial coiling for lung volume reduction (LVR) by comparison with clinical (6 meter walk test [6MWT]) and pulmonary function tests (PFT).

22 lobes in 17 patients (8 men, 9 female; mean age 66.2 ± 5.9 years) with severe heterogeneous emphysema were treated by endobronchial coils and underwent pre-and post-interventional CT-examinations (inspiratory & expiratory phase). Clinical response was defined as an increase in the walking distance (6MWT) after LVR-therapy. PFT measurements with forced expiratory volume in 1 second (FEV1), ratio of residual volume over total lung capacity (RV/TLC) and single-breath diffusion capacity for carbon monoxide (DLCOSB) were used for correlation.

Responders (N=14) presented a significant increase (70 ± 11 m) in the walking distance (6MWT) and FEV1-values (61 ± 21 ml). In non-responders, walking distance significantly decreased (70 ± 15 m) and the results of PFT did not improve. Inspiratory volume (VolIn) of the target lobe significantly decreased (10.0 ± 16.4 %; p-value = 0.0245) compared to pre-interventional lobe volume in responders, while no marked volume change could be detected in non-responders. VolIn of the non-treated ipsilateral lobe significantly increased in responders (5.5 ± 9.1 %; p-value = 0.0209) while the increase of VolIn of the contralateral lung did not reach statistical significance.

Our results objectify volume reduction of the treated lobe coupled by a significant volume expansion of the ipsilateral lobe as a sole correlate for clinical improvement in responders.

The results of this preliminary study demonstrate the interplay between treated and untreated lung lobes with respect to volume and density changes in patients treated with LVR-coils.

Grosse, U, Hetzel, J, Guendel, L, Gatidis, S, syha, r, Schabel, C, Springer, F, Claussen, C, Nikolaou, K, Horger, M, Impact of Endobronchial Coiling for Lung Volume Reduction on Pulmonary Volume and Attenuation: Pre- and Post-interventional CT-quantification using Separate Lobe Measurements.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011652.html