Stefanie Bettina Weigel, Presenter: Nothing to Disclose

Oliver Heidinger, Abstract Co-Author: Nothing to Disclose

Jan Heidrich, Abstract Co-Author: Nothing to Disclose

Shoma Berkemeyer, Abstract Co-Author: Nothing to Disclose

Walter Leonhard Heindel MD, Abstract Co-Author: Nothing to Disclose

Hans Werner Hense, Abstract Co-Author: Nothing to Disclose

To investigate the association between age and detection rates of ductal carcinoma in situ (DCIS), separately for different nuclear grades, after introduction of a population-based digital mammography screening program (MSP).

740,200 women participating for the first time in the MSP between 2005 and 2008 were examined in 17 screening units. We calculated DCIS detection rates (DetR‰; per 1,000 women screened) in 5-years age groups distinguishing DetR‰ for low (n=189), intermediate (n=405) and high grade (n=436) DCIS. Likewise, the relative contribution of each nuclear grade was calculated as a proportion of the overall DetR‰. Data analyses accounted for variation between screening units using multivariate regression techniques.

The DetR‰ for total DCIS increased from younger to older age groups (50-54 yrs.: 1.22; 55-59 yrs.: 1.27; 60-64 yrs.: 1.37; 65-69 yrs.: 1.74; p=0.0008). The DetR‰ for high grade DCIS showed a significant trend with age (+ 0.09 per 5 years; p=0.0017); the trend for intermediate grade DCIS was of borderline significance (+0.05 per 5 years; p=0.055). Of note, the DetR‰ for low grade DCIS did not significantly differ between the age groups (+0.02 per 5 years; p=0.18). In terms of DCIS proportions, 42.3% were on average high grade, 39.3% intermediate grade and 18.3% low grade DCIS and there was no significant influence of age.

Overall DCIS detection rates increase with age groups which is mostly due to a rise of detection rates of DCIS high and intermediate grade, i.e., precursor lesions that carry a higher risk for transition to invasive breast cancer than DCIS low grade.

Increasing detection rates of more progressive DCIS subtypes in increasing age groups with highest rates in the age group 65-69 years rise questions to extend the upper age limit for organized mammography screening programs.

Weigel, S, Heidinger, O, Heidrich, J, Berkemeyer, S, Heindel, W, Hense, H, Digital Mammography Screening: Does Age Influence the Detection Rates of Low, Intermediate and High Grade Ductal Carcinoma in Situ?  .  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011597.html