Peter Minko MD, Presenter: Speaker, Straub Medical AG Consultant, Straub Medical AG

Matthias Klingele, Abstract Co-Author: Nothing to Disclose

Jonas Stroeder MD, Abstract Co-Author: Nothing to Disclose

Heinrich Groesdonk, Abstract Co-Author: Nothing to Disclose

Arno Buecker MD, Abstract Co-Author: Consultant, Covidien AG Speaker, Covidien AG Co-founder, Aachen Resonance GmbH Research Grant, Siemens AG

Hans-Joachim Schafers MD, Abstract Co-Author: Nothing to Disclose

Marcus Katoh MD, Abstract Co-Author: Consultant, Straub Medical AG Consultant, Medtronic, Inc

To correlate angiographic findings with kidney specific parameters and to investigate the predictive value of angiography with respect to the outcome in patients with NOMI.

In this prospective study 63 consecutive patients (mean age:73±8 years) suspected of NOMI after cardiac or major thoracic vessel surgery underwent catheter angiography of the superior mesenteric artery. Images were assessed by two experienced radiologists on consensus basis using a previously published standardized reporting system (Homburger-NOMI-Score). These data were correlated to kidney specific parameters: FGF-23, cystatin, cystatin C, creatinin and glomerular filtration rate (GFR) and outcome data (death, acute renal failure) using linear and logistic regressions, as well as nonparametric test and ROC-analysis.

Significant correlations were found between FGF-23 and the overall NOMI-score (consisting of five categories namely vessel morphology, reflux of contrast medium into the aorta, contrast enhancement and distension of the intestine, as well as the time to portal vein filling; p=0.05) as well as the modified NOMI-score (consisting of three categories namely vessel morphology, reflux of contrast medium into the aorta and time to portal vein filling; p=0.02). No significant correlation was found for creatinin (p=0.07), cystatin (p=0.27), cystatin C (p=0.83) and GFR (p=0.23). Logistic regression revealed a significant correlation between death and the overall NOMI-score (p=0.006) as well as the modified NOMI-score (p<0.001). No significant correlation was found for the development of acute renal failure (p=0.268).

FGF-23 significantly correlates with the development of NOMI. Furthermore the applied scoring system allows to predict fatal outcome in NOMI patients.

FGF-23 plays a predictive value for the devolpment of NOMI and corelates significantly with the Homburger-NOMI-Score.

Minko, P, Klingele, M, Stroeder, J, Groesdonk, H, Buecker, A, Schafers, H, Katoh, M, FGF-23 a Predictive Parameter in Patients with Non-occlusive Mesenteric Ischemia (NOMI).  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011592.html