Henry Ho Ching Tam MBBS, Presenter: Nothing to Disclose

Ying Chen MBBS, Abstract Co-Author: Nothing to Disclose

Dow-Mu Koh MD, FRCR, Abstract Co-Author: Nothing to Disclose

Adil Al-Nahhas, Abstract Co-Author: Nothing to Disclose

The incidence of both primary and secondary liver malignancies is increasing. Although surgery or minimally invasive intervention e.g. radiofrequency ablation results in the best outcomes, these approaches are limited by the burden and site of disease. Selective internal radiation therapy (SIRT) is a promising technique in patients deemed unsuitable for surgery. Despite its increasing popularity, radiologists may not be familiar with this treatment. Review the principle of SIRT with yttrium-90 (90Y) microspheres Review the literature with regards to treatment outcomes. Although morphological imaging is usually used to assess disease burden and treatment response, the potential for functional imaging techniques is discussed. 

Physics and biological basis of SIRT with yttrium-90 Comparison of the properties of SIR-spheres with Theraspheres Patient selection/contraindications Patient preparation: visceral angiography (Fig. 1); hepatopulmonary shunt (Fig. 2 and 3); dosimetry Adverse reactions and complications Special consideration in patients with portal vein thrombosis and malignant biliary obstruction Morphologic and functional imaging techniques for response assessment and prediction (Fig. 4 & 5) Review of published data supporting use of 90Y-SIRT: response rate and long-term outcome

http://abstract.rsna.org/uploads/2014/14011498/14011498_n77h.pdf

Tam, H, Chen, Y, Koh, D, Al-Nahhas, A, Selective Internal Radiation Therapy (SIRT) – A Review on the Principle, Work-up and Overview of Published Data in Selective Internal Radiation Therapy with Yttrium-90 Microspheres.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011498.html