Anwar Roshanali Padhani MD, Presenter: Advisory Board, Acuitas Medical Ltd Advisory Board, Siemens AG Speakers Bureau, Siemens AG Researcher, Siemens AG Speakers Bureau, Johnson & Johnson

Giuseppe Petralia MD, Abstract Co-Author: Nothing to Disclose

Heminder Kaur Sokhi MRCS, FRCR, Abstract Co-Author: Nothing to Disclose

Francesco Sanguedolce PhD, MD, Abstract Co-Author: Nothing to Disclose

Giles Hellawell MD, MRCS, Abstract Co-Author: Nothing to Disclose

Nicola Anyamene, Abstract Co-Author: Nothing to Disclose

• Multiparametric (diffusion weighted, dynamic contrast enhancement and spectroscopy) MRI (mpMRI) has the potential to improve patient selection at initial triage for active surveillance (AS) • Changing mpMRI phenotype during AS should prompt histologic sampling to assess for interval disease upgrading prior to AS discontinuation • Physician communication via structured, pictorial reporting is key to the successful implementation of mpMRI for AS

• Overview of the concepts underpinning AS strategies for low risk prostate cancer patients • Discuss contemporary challenges for AS • Illustrate the ability of mpMRI to delineate tumor location, extent & grade • Discuss the role of mpMRI for confirming clinical patient selection criteria for AS & potential to replace early confirmatory biopsy • Demonstrate the ability of mpMRI to predict adverse pathological features thus to detect the approximately 30% of patients currently misclassified who are unsuitable for AS • Illustrate the changing imaging phenotype during the AS period which should prompt out-of-program histologic resampling • Demonstrate structured pictorial reporting of mpMRI using the ESUR PI-RADS system • Discuss guidelines advocating implementation of mpMRI in routine management of AS candidates

http://abstract.rsna.org/uploads/2014/14011467/14011467_6klc.pdf

Padhani, A, Petralia, G, Sokhi, H, Sanguedolce, F, Hellawell, G, Anyamene, N, Role of Multiparametric MRI for Managing Active Surveillance of Prostate Cancer Patients.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011467.html