Michael Haimerl, Abstract Co-Author: Nothing to Disclose

Niklas Verloh, Abstract Co-Author: Nothing to Disclose

Claudia Fellner MD, PhD, Abstract Co-Author: Nothing to Disclose

Marcel Dominik Nickel, Abstract Co-Author: Employee, Siemens AG

Florian Zeman, Abstract Co-Author: Nothing to Disclose

Christian Roland Stroszczynski MD, Abstract Co-Author: Nothing to Disclose

Philipp Wiggermann, Presenter: Nothing to Disclose

To determine whether liver function expressed by the indocyanine green clearance (ICG) could be estimated quantitatively from hepatic magnetic resonance (MR) - relaxometry with Gd-EOB-DTPA.

108 consecutive patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MR including MR–relaxometry. ICG-test were performed 24 h prior or 24 h post MRI to eliminate any confounding with MR – Relaxometry. After acquisition of a B1 map for inline correction of B1 inhomogeneities a prototypical transverse 3D VIBE sequence (TR 5.79 ms, TE 2.46 ms, α 1°, 7°, 14°) with inline T1 calculation was acquired prior and 20 minutes post Gd-EOB-DTPA (0.025 mmol per kilogram of body weight) administration. Volumetric mean T1 relaxation time of liver (volT1t) and reduction rate of T1 relaxation time (rrT1) between pre- and postcontrast were evaluated. The plasma disappearance rate of ICG (ICG-PDR) and ICG (R 15) value were correlated with volT1t and rrT1.

Linear regression showed significant correlation of ICG- PDR with rrT1 (B = 47.7; p< 0.001; R2 = 0.561) and ICG (R 15) (B = -96.3; R2 = 0.561; p<0.001). Assessment of liver volumina and consecutive evaluation of multiple linear regression model showed strong correlation of ICG- PDR with volT1t (B liver volume = 0.006; B reduction rate = 49.0; R2 = 0.679; p<0.001) and ICG (R15) with volT1t (B liver volume = -0.014; B reduction rate = -99.3; R2 = 0.848; p<0.001).

Liver function expressed through ICG-PDR and ICG (R15) can be estimated quantitatively from MR - Relaxometry with Gd-EOB-DTPA.

Volumetric T1 mapping by means of non-enhanced and Gd-EOB-DTPA- enhanced MRI may provide suitable parameter for evaluation of liver function, may be useful for monitoring disease progression and has the potential to become a novel index of global and remnant liver function.

Haimerl, M, Verloh, N, Fellner, C, Nickel, M, Zeman, F, Stroszczynski, C, Wiggermann, P, Volumetric Estimation of Liver Function Based on MR - Relaxometry with Gd-EOB-DTPA.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011442.html