Soham Banerjee BS, Presenter: Nothing to Disclose

Kevin S. King MD, Abstract Co-Author: Nothing to Disclose

Roderick McColl PhD, Abstract Co-Author: Nothing to Disclose

Anthony R. Whittemore MD, Abstract Co-Author: Nothing to Disclose

Keith Hulsey, Abstract Co-Author: Nothing to Disclose

Ronald M. Peshock MD, Abstract Co-Author: Nothing to Disclose

To identify the spatial distribution of white matter hyperintensity (WMH) associated with hypertension, diabetes, hypercholesterolemia.

MRI brain images were obtained from 2066 adult participants (858 males, 1208 females; mean age: 50) from a population based sample. An automated algorithm generated each participant’s WMH distribution registered onto the MNI-152 standard template. For univariate analysis, each risk factor group was compared to the non-risk factor group. Voxels in which WMH frequency was significantly higher (p<0.05) in the risk factor group were mapped. Multivariate analysis consisted of subgroup analysis to minimize confounding of one risk factor on the others.

431891 MNI-space voxels comprised WMH distribution of the entire population. For univariate analysis, 26064 voxels (6%) of these voxels were exclusively associated with hypertension and were prevalent in the anterior frontal lobe. Similarly, 22527 voxels (5%) were exclusively associated with diabetes and were prevalent at the callososeptal interface. 8088 voxels (2%) were only associated with hypercholesterolemia and did not form a discrete spatial distribution. Multivariate results corroborated the univariate findings.

Each risk factor was associated with a unique spatial distribution of WMH. Hypertension was associated with WMH in the anterior frontal lobe and diabetes was associated with WMH in the callososeptal interface.

Findings of WMH in the anterior frontal lobe of hypertensives and the callososeptal interface of diabetics should raise concern for end organ damage and consideration for aggressive medical therapy.

Banerjee, S, King, K, McColl, R, Whittemore, A, Hulsey, K, Peshock, R, Cardiovascular Risk Factors Predict the Spatial Distribution of White Matter Hyperintensity.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011363.html