Meike Weidner, Presenter: Nothing to Disclose

Melissa Winkler, Abstract Co-Author: Nothing to Disclose

Claudia Hagelstein MD, Abstract Co-Author: Nothing to Disclose

Christel Weiss, Abstract Co-Author: Nothing to Disclose

Stefan Oswald Schoenberg MD, PhD, Abstract Co-Author: Institutional research agreement, Siemens AG

Thomas Schaible, Abstract Co-Author: Nothing to Disclose

Wolfgang Neff MD, PhD, Abstract Co-Author: Nothing to Disclose

Most prenatal prognostic parameters in congenital diaphragmatic hernia (CDH) refer to a healthy control group. The prenatally measured MR based ratio of fetal lung volume to fetal body volume (FLV/FBV) can be calculated individually. This study investigated the prognostic value of this ratio with regard to the development of chronic lung disease (CLD).

MRI was performed in 132 fetuses with diagnosed CDH. Both FLV and FBV were measured and used to calculate the ratio of FLV/FBV. CLD was diagnosed if oxygen was required at postpartum day 28. Logistic regression analysis was used to model the dependence of CLD on the ratio. Prognostic accuracy was evaluated by applying the area under the curve (AUC) in receiver operating characteristics (ROC) analysis.

61 of 132 children (46%) developed CLD postnatally. Neonates who developed a CLD showed prenatally a significantly reduced ratio (FLV/FBV) of 0.011±0.005 in comparison to children without the diagnosis of CLD (0.014±0.005; p=0.0008). A higher ratio of FLV to FBV was associated with a reduced probability of CLD-development. In ROC-analysis, the AUC in this context was 0.743.

The MRI based ratio (FLV/FBV) is a prenatal predictor for the development of CLD in children with CLD. It is calculated individually and therefore independent of a control group.

The individually calculated ratio of FLV to FBV is able to predict the probability of CLD-development prenatally. Its independency of a control group may be an advantage in particular in growth restricted children.

Weidner, M, Winkler, M, Hagelstein, C, Weiss, C, Schoenberg, S, Schaible, T, Neff, W, Magnetic Resonance Imaging Based Ratio of Fetal Lung Volume to Fetal Body Volume as a New Prognostic Marker for the Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14011193.html