Hideyuki Nishiofuku, Presenter: Nothing to Disclose

Toshihiro Tanaka MD, Abstract Co-Author: Nothing to Disclose

Yasushi Fukuoka, Abstract Co-Author: Nothing to Disclose

Takeshi Sato, Abstract Co-Author: Nothing to Disclose

Hiroshi Anai MD, PhD, Abstract Co-Author: Nothing to Disclose

Kimihiko Kichikawa MD, Abstract Co-Author: Nothing to Disclose

Shinsaku Maeda, Abstract Co-Author: Nothing to Disclose

Tetsuya Masada, Abstract Co-Author: Nothing to Disclose

Rat liver tumor models have been improved and are widely used for various preclinical studies in interventional oncology. Most of the previous studies of intra-arterial therapy were performed under laparotomy, with the insertion of catheter via gastroduodenal artery. Recently, image-guided angiographic techniques have been developed. The purpose of this exhibit is: (1) To learn about the techniques of preparation of rat liver tumor models. (2) To learn about the interventional techniques for intra-arterial therapy in rat. (3) To learn about the anatomical variations of hepatic artery in rat.

【Contents】 (1) Cell culture methodologies and tumor implantation procedures, e.g. direct injection, portal vein injection and splenic parenchymal injection. (2) Tumor cell lines and animal models in terms of hepatocellular carcinoma and colorectal cancer, e.g. McA-RH7777 in SD rat and RCN-9 in F344 rat. (3) Transcatheter arteriography techniques, carotid artery approach and femoral approach with/without the combination of laparotomy. (4) Type and frequency of the anatomical variations of hepatic artery. (5) Applications for clinical studies. 【Summary】 Image-guided intra-arterial therapy in rat liver tumor model is feasible and useful for preclinical studies in interventional oncology.

http://abstract.rsna.org/uploads/2014/14010851/14010851_2yxv.pdf

Nishiofuku, H, Tanaka, T, Fukuoka, Y, Sato, T, Anai, H, Kichikawa, K, Maeda, S, Masada, T, Technical Recommendations for Intra-arterial Therapy in Rat Liver Tumor Model.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14010851.html