Jingjing Xing MD, Presenter: Nothing to Disclose

Jianbo Gao MD, Abstract Co-Author: Nothing to Disclose

Hangsha Hang Limbu MD, Abstract Co-Author: Nothing to Disclose

Yonggao Zhang, Abstract Co-Author: Nothing to Disclose

pan liang, Abstract Co-Author: Nothing to Disclose

To analyze the iodine concentration(IC), normalized iodine concentration (nIC) and water concentration (WC) of the perigastric fat tissue adjacent to the tumor lesion and correlate their value for differentiating between T3 and T4 staged gastric carcinoma.

Fifty-four patients with pathologically proven T4 (group A) and T3 (group B) staged gastric carcinoma who had undergone spectral CT imaging (Discovery CT750 HD) were retrospectively selected. Material Decomposition (MD) image of these cases were reconstructed for measuring IC, nIC and WC of perigastric fat tissue adjacent to the lesion during Arterial phase (AP) and Venous phase (VP). Two-sample t tests were used to compare the three parameters between group A and group B during AP and VP. Receiver operating characteristic (ROC) was used to determine the threshold of nIC for differentiating T3 and T4 staged gastric carcinoma.

Significantly higher IC and nIC values were obtained in group A than in group B (IC -0.72±2.01 vs. -7.00±0.31 µg/cm3 in AP; 0.15±2.18 vs. -5.00±2.21µg/cm3 in VP; nIC 0.03±0.22 vs. -0.07±0.31 in AP; 0.22±0.42 vs. -0.10±0.65 in VP) (P<0.05). There was no significant difference in water concentration during both AP and VP (p>0.05). Setting the threshold of nIC at -0.048 during AP and -0.015 during VP, the sensitivity of serosal invasion was 85.2% and 82.3% respectively and specificity of serosal invasion was 87.6% and 82.3% respectively.

The iodine concentration of perigastric fat adjacent to the tumor is significantly higher in cases of T4 staged gastric carcinoma to that of T3 staged gastric carcinoma and can be regarded as a definitive sign of serosal invasion. 

Iodine concentration of perigastric fat tissue adjacent to tumor accurately detects serosal invasion and can be implemented in CT staging of gastric carcinoma preoperatively.

Xing, J, Gao, J, Limbu, H, Zhang, Y, liang, p, Iodine Concentration in Perigastric Fat Tissue Adjacent to the Tumor and its Correlation to T Staging of Gastric Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14010797.html