Deepa Prasad MBBS, MD, Presenter: Nothing to Disclose

Anna Marie West BS, Abstract Co-Author: Nothing to Disclose

apurva bansal MBBS, Abstract Co-Author: Nothing to Disclose

Ravi Ashwath MD, Abstract Co-Author: Nothing to Disclose

It has been well established that cardiac MRI (CMR) T2 Star (*) is a useful technique to evaluate myocardial iron concentration by the use of gradient echo. T2* has been shown to correlate well with left ventricular ejection fraction (LVEF) in these patients. Functional quantification of ventricles is time consuming. Echo derived mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE) are quick and easily reproducible parameters, which have been shown to be good surrogates of LV and RV function in adult patients. CMR derived MAPSE and TAPSE have not been studied sufficiently in the pediatric population. The purpose of this study is to demonstrate correlation between MAPSE, TAPSE, ventricular function and T2 * in children with myocardial iron overload.

A retrospective study of 37 patients with transfusion dependent anemia was performed. LVEF and RVEF were obtained from short axis cine images utilizing 1.5 T CMR scanner. T2* was obtained by the use of single breath hold, multiecho acquisition with a constant TR. MAPSE and TAPSE were derived from cine images obtained from ventricular long axis views. All the above parameters were analyzed to assess correlation using Spearman’s correlation, r >0.3 and P < 0.05 were considered significant.

A linear moderate positive correlation was noted between LVEF and MAPSE (r=0.42, P< 0.05). T2* showed linear positive correlation with LVEF  (r=0.34, P<0.05) but no correlation with MAPSE. However, in the group with T2* <35 msec, there was a linear positive correlation noted between T2 star and MAPSE (R=0.34, P<0.05). There was no correlation between T2*, RVEF and TAPSE.  

MAPSE correlates with T2*< 35 msec and LVEF, and it could prove to be a sufficient surrogate for LV function assessment and potentially replace the time consuming LVEF assessment by CMR in a selective group of children with iron overload.  

MAPSE correlates well with LVEF and can potentially replace the time consuming LVEF estimation by CMR in patients with iron overload.

Prasad, D, West, A, bansal, a, Ashwath, R, Correlation of Cardiac MRI Derived MAPSE, TAPSE, Ventricular Function and T2 Star in Children with Iron Overload.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14010735.html