Heitor Castelo Branco Rodrigues Alves MD, Presenter: Nothing to Disclose

Renato Hoffmann Nunes MD, Abstract Co-Author: Nothing to Disclose

Antonio Rocha, Abstract Co-Author: Nothing to Disclose

Lazaro F. Amaral MD, Abstract Co-Author: Nothing to Disclose

To review the pathophysiology of X-Linked adrenoleukodystrophy (X-ALD) To review recognizable neuroimaging patterns of X-ALD Emphasizing atypical brain patterns in X-ALD using conventional MRI. Reviewing the role of advanced MR techniques to better comprehend in vivo X-ALD pathophysiology.  

X-Linked adrenoleukodystrophy (X-ALD) is a peroximal disorder that has a wide range of clinical manifestations. Usually, X-ALD presents with bilateral symmetric involvement of the parieto-occipital white matter (WM). However, different MR imaging patterns have been described that do not conform to the typical pattern. Our current aim was to study a selected series of X-ALD patients (n=12) with unusual MR findings to didactically list recognizable features, including topography and Gd-enhancement patterns. Frontal lobe (anterior pattern), exclusive unilateral (infra or supratentorial disease) and also, either diffuse bilateral, posterior or anterior asymmetrical WM lesions were all scrutinized. Advanced MR techniques, including DTI, MTC and MRS, were useful to show involved structures and to detect early T2/FLAIR unsuspected WM involvement. Radiologists must be aware to recognize X-ALD based on both conventional and advanced MR techniques, in its typical or atypical presentations of this rare disease.  

http://abstract.rsna.org/uploads/2014/14010621/14010621_m9bv.pdf

Alves, H, Nunes, R, Rocha, A, Amaral, L, X-Linked Adrenoleukodystrophy MRI: A Pictorial Essay to Emphasize Unusual Patterns.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14010621.html