Abstract Archives of the RSNA, 2014
Hye Mi Gweon MD, Presenter: Nothing to Disclose
Eun Ju Son MD, PhD, Abstract Co-Author: Nothing to Disclose
Ji Hyun Youk MD, Abstract Co-Author: Nothing to Disclose
Jeong-Ah Kim MD, PhD, Abstract Co-Author: Nothing to Disclose
To determine the utility of galectin-3 in preoperative fine-needle aspiration (FNA) cytology for papillary thyroid microcarcinoma (PTMC)
Between June 2011 and December 2012, 530 consecutive patients with PTMC who underwent surgery and preoperative ultrasonography (US)-guided FNA with galectin-3 immunostaining were reviewed. Galectin-3 considered positive if the percentage of tumor cells showing definite cytoplasmic immunostaining exceeded 5 %. US features and clinicopathologic results were compared between PTMC with galectin-3 positive and negative. Fisher exact test or chi-square test was used for statistical analysis. The median tumor size was 6 mm (range, 1-10 mm).
Of the 530 PTMCs, 203 (38.3%) PTMCs had galectin-3 positive in preoperative FNA samples. There was no significant difference in US features between galectin-3 positive and negative PTMCs. There was no significant correlation in extracapsular invasion (43.8% vs. 40.1%, p=0.415) and lymph node metastasis (27.1% vs. 24.2%, p=0.473).
The sensitivity of galectin-3 in FNA samples was low (38.3%) in PTMC. Preoperative expression of galectin-3 in FNA cytology did not correlate with US findings nor associate with pathological parameters such as extracapsular invasion and LN metastasis in PTMC.
Previous published studies reported high sensitivity and diagnostic accuracy of galectin-3 for distinguishing benign and malignant thyroid nodules and significant correlation with galectin-3 expression and clinicopathologic results. However, galectin-3 in FNA cytology may be not useful for small thyroid nodule less than 10 mm.
Can Galectin-3 be a Useful Marker for Papillary Thyroid Microcarcinoma?. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14010156.html