Patrick Freyhardt MD, Presenter: Nothing to Disclose

Ricardo Donners, Abstract Co-Author: Nothing to Disclose

Alex Riemert, Abstract Co-Author: Nothing to Disclose

Joerg Schnorr, Abstract Co-Author: Nothing to Disclose

Nicola Stolzenburg, Abstract Co-Author: Nothing to Disclose

Jan-Leo Rinnenthal, Abstract Co-Author: Nothing to Disclose

Rolf Wilhelm Guenther MD, Abstract Co-Author: Nothing to Disclose

Bernd K. Hamm MD, Abstract Co-Author: Research Consultant, Bayer AG Research Consultant, Toshiba Corporation Stockholder, Siemens AG Stockholder, General Electric Company Research Grant, Toshiba Corporation Research Grant, Koninklijke Philips NV Research Grant, Siemens AG Research Grant, General Electric Company Research Grant, Elbit Medical Imaging Ltd Research Grant, Bayer AG Research Grant, Guerbet AG Research Grant, Bracco Group Research Grant, B. Braun Melsungen AG Research Grant, KRAUTH medical KG Research Grant, Boston Scientific Corporation Equipment support, Elbit Medical Imaging Ltd Investigator, CMC Contrast AB

Florian Streitparth, Abstract Co-Author: Nothing to Disclose

To evaluate feasibility, safety and efficacy of renal sympathetic denervation with CT-guided needle-based percutaneous periarterial injection of vincristin in pigs.

Percutaneous unilateral periarterial injection of 10 ml of a mixture of Vincristin 0,1 mg dissolved in 0,9% Saline, Bupivacaine and Accupaque 250 (ratio 7:2:1) was performed in 6 normotensive pigs. Needle placement and injections were performed under CT-guidance in all animals. Blood pressure measurements and CT scans of the kidneys perirenal structures were performed immediately pre- and post intervention and 4 weeks after treatment. After euthanasia Norepinephrine (NE) concentration of both kidneys was determined. The renal arteries and the surrounding tissue were examined histologically to look for induced nerve fibre degeneration.

All procedures were technically successful with good periarterial distribution of the injectant. No major events occurred. No postinterventional complications were observed. NE concentration of the renal parenchyma was significantly lower on the treated side in all pigs with a mean decrease of 53,5% (min: 43%, max: 66%) compared to the contralateral untreated kidney. Histological examination revealed neural degeneration in all animals.

CT-guided needle-based percutaneous periarterial Vincristin injection for renal sympathetic degeneration was feasible, effective and safe. This approach may be an alternative to the catheter-based techniques in the treatment of therapy resistant hypertension.

Renal sympathicolysis by percutaneous periarterial Vincristin may be an alternative to catheter-based techniques. Apart from efficacy the procedure is less invasive and faster than RFA-based methods.

Freyhardt, P, Donners, R, Riemert, A, Schnorr, J, Stolzenburg, N, Rinnenthal, J, Guenther, R, Hamm, B, Streitparth, F, Renal Sympathicolysis by Percutaneous Periarterial Injection of Vincristin—A Feasibility Study in Pigs.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14010150.html