Li Liu MD, Presenter: Nothing to Disclose

Bo Yin MD, Abstract Co-Author: Nothing to Disclose

Weijun Peng MD, Abstract Co-Author: Nothing to Disclose

To investigate 1)use of quatitative analysis of T2 relaxtion time in differentiating malignant from benign breast lesions and therefore increase the diagnostic acuracy of breast MRI; 2)change in T2 relaxation time of breast cancer before and after neoadjuvant chemotherapy (NAC).

Of the total 67 patients, 46 have malignant tumors while 21 have benign pathology.Twenty-six of the 47 malignant cases underwent NAC. MRI T2mapping was performed in all patients. In patients with NAC, T2-mapping was performed before and after NAC. T2 relaxation times were obtained by using Funtool softeware on AW 43 workstation. Pathological response to NAC was assessed according to Miller＆Payne response score. Statistical analysis was performed on T2 relaxation times of malignant and benign lesions, before and after NAC. 

The mean T2 relaxation time in the malignant cases was 82.69 ±15.37ms, whereas the T2 relaxation time in benign cases was 95.48±26.51ms. Difference in T2 relaxation time betweenmalignant and benign cases is statistically significant（P=0.015 <0.05）．In 26 cases with NAC,the mean T2 relaxation time was 81.34±13.68msand 64.50±8.71ms before and after NAC respectively. Difference in T2 relaxation time between the pre— and post— NAC is significant（P=0.00<0.05）. Based on the MP response score, the mean post-NAC T2 relaxation time in 23 responders out of 26 NAC cases (63.18±8.37ms ) was significantly shorter than that in non-responders (74.62±2.32ms)(P=0.029＜0.05）. 

T2 relaxation time in benign lesions was found to be significantly longer than that in malignant lesions. Quantitative measurement of T2 relaxation time might provide new diagnostic parameter to breast MRI. T2 relaxation time in breast cancer was reduced after NAC, particularly in the responders. Measurement of T2 relaxation time change is a potential new tool to assess the response to NAC.

Measurement of T2 relaxation time change is a potential new tool to assess the response to NAC and dignosis breast cancer.

Liu, L, Yin, B, Peng, W, Role of T2 Mapping in Diagnosis and Neoadjuvant Chemotherapy of Breast Cancer.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14009803.html