Kim Lee MD, Presenter: Nothing to Disclose

Anna Shmukler MD, Abstract Co-Author: Nothing to Disclose

Benjamin Zalta MD, Abstract Co-Author: Nothing to Disclose

Linda Broyde Haramati MD, MS, Abstract Co-Author: Investor, OrthoSpace Ltd Investor, Kryon Systems Ltd Spouse, Board Member, Bio Protect Ltd Spouse, Board Member, OrthoSpace Ltd Spouse, Board Member, Kryon Systems Ltd

The purpose of this exhibit is to: 1) Review the pathophysiology of SLE focusing on the development of the antibodies to native dsDNA, as they are relatively specific for the diagnosis of SLE 2) Identify and describe thoracic imaging manifestations of SLE on chest CT. 3) Discuss the pulmonary function abnormalities associated with SLE. 4) Correlate imaging findings with smoking status, pulmonary function tests, and double-stranded DNA (dsDNA) serology.

Review of pathophysiology of SLE Review of cases demonstrating chest CT findings in SLE    Airway involvement- Bronchiectasis    Parenchymal disease- From ground glass opacities and linear opacities to manifestations of fibrosis including       honeycombing and architectural distortion     Pleural Involvement- Pleural Effusions, Pleural Thickening     Cardiac Involvement- Cardiomegaly, Pericardial effusions,Pericardial Thickening     Pulmonary Embolism     Pulmonary Hypertension     Lymphadenopathy- Axillary, Mediastinal, Hilar     Esophageal disease- Esophageal dilatation, Esophageal thickening    Upper abdominal findings- Splenomegaly, Lymphadenopathy Discussion of correlations between smoking status and PFTs with imaging abnormalities in SLE Discussion of correlations between dsDNA serology with imaging abnormalities in SLE Future directions and summary

http://abstract.rsna.org/uploads/2014/14009665/14009665_6zgt.pdf

Lee, K, Shmukler, A, Zalta, B, Haramati, L, Just Breathe! A SLEw of CT Findings in SLE Patients with Thoracic Involvement and Correlations with Serology, Smoking and PFT's.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14009665.html