Victoria Chernyak MD, Presenter: Nothing to Disclose

Milana Flusberg MD, Abstract Co-Author: Nothing to Disclose

Linda Broyde Haramati MD, MS, Abstract Co-Author: Investor, OrthoSpace Ltd Investor, Kryon Systems Ltd Spouse, Board Member, Bio Protect Ltd Spouse, Board Member, OrthoSpace Ltd Spouse, Board Member, Kryon Systems Ltd

Eran Bellin, Abstract Co-Author: Nothing to Disclose

Alla M. Rozenblit MD, Abstract Co-Author: Nothing to Disclose

To compare the imaging follow-up and all-cause mortality in subjects >65 years with and without incidental pancreatic cysts (IPC).

The study population comprised of subjects >65 years who underwent abdominal CT/MR 11/1/01-11/1/11. IPC group included subjects whose CT/MRs reported an IPC; No-IPC group was 3:1 frequency-matched on age decade, imaging modality and year of initial study from the pool without reported IPC. Demographics, date of last encounter, date of death, Charlson scores within 3 months before initial CT/MR and number of abdominal CTs and MRs performed after initial study were extracted from the hospital database. Logistic regression models with binary outcomes of death and having imaging follow-up were constructed. The models were adjusted for age, race, sex, Charlson score and follow-up time.

There were 1,320 subjects in IPC group and 3,806 in No-IPC group, with mean ages 69.9 (±15.1) and 69.3 (±15.2) years, respectively (p=0.13), and mean follow-up times of 2.9 (±2.6) and 3.1 (±2.6) years, respectively (p=0.02). Women comprised 66.9% (883/1,320) of IPC group and 60.7% (2,309/3,806) of No-IPC group (p<0.001). Adjusted odds ratios (A-OR) of IPC for death were 1.2 (p=0.23) in subjects ≤80 years and 0.7 (p=0.01) in subjects >80 years. A-OR of IPC for having imaging follow-up were 2.8 (p<0.001) in subjects ≤80 years and 1.2 (p=0.07) in subjects >80 years. Of the subjects ≤80 years with imaging follow-up, mean total numbers of studies were 4.5 (±4.4) in IPC group and 3.3 (±3.3) in No-IPC group (p<0.001). Of the subjects >80 years with imaging follow-up, mean numbers of studies were 3.1 (±2.8) in IPC group and 2.4 (±2.1) in No-IPC group (p<0.001). Number of follow-up studies was not an independent predictor of death in subjects with IPC and imaging follow-up (A-OR=1.0, p=0.96).

The older subjects with IPC are more likely to undergo imaging follow-up and with a higher mean number of studies as compared to subjects without IPC, yet the odds of death are either equal (65-80 years) or decreased (>80 years) in subjects with IPC as compared to those without IPC, and the odds of death are not affected by number of follow-up studies.

IPC in older subjects have no association with higher all-cause mortality, and the number of follow-up studies is not associated with lower all-cause mortality, thus fewer number of surveillance studies may be appropriate in older subjects with IPC.

Chernyak, V, Flusberg, M, Haramati, L, Bellin, E, Rozenblit, A, Incidental Pancreatic Cysts: Imaging Follow-up and All-cause Mortality in Older Subjects.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14009524.html