Li Na Zhang MD, Presenter: Nothing to Disclose

Song Chen, Abstract Co-Author: Nothing to Disclose

Shao Wu Wang MD, Abstract Co-Author: Nothing to Disclose

Qingwei Song BS, BEng, Abstract Co-Author: Nothing to Disclose

Ailian Liu MD, Abstract Co-Author: Nothing to Disclose

To evaluate the breast characteristics of invasive cancers on dynamic contrast-enhanced MR imaging (DCE-MRI) and diffusion-weighted MR imaging (DWI) assessed as parameters in comparison with different molecular subtypes.

This retrospective study was approved by the institutional review board and requirement for informed consent was waived. A total of 164 lesions in 161 women who underwent preoperative breast imagings both DCE-MRI and DWI were reviewed. According to the receptor status, tumour subtype was categorized as triple-negative breast cancer (TNBC), luminal A, luminalB, and Herb 2+.The following lesion characteristics were recorded: DCE morphology and maximum lesion size, initial phase peak enhancement,delayed phase enhancement categorized by a single type of kinetics comprising the largest percentage of enhancement (washout, plateau, or persistent) with CAD analysis, apparent diffusion coefficient (ADC) values, and contrast-to-noise ratio (CNR) at DWI with b values of 0 and 800 s/mm2. Discriminative abilities of models were compared by using the area under the receiver operating characteristic curve(AUC).  

Compared with other three subtypes (69luminal A, 40luminalB, and 21Herb 2+), TNBC lesions exhibited smooth mass margin, larger maximum lesion size and rim enhancement (n=34,P<0.005).Significant differences in delayed phase enhancement (P<0.005)and CNR(P<0.001) were observed among four subtypes,while no differences in lesion shape(p=0.09), initial phase peak enhancement parameters(P=0.07) or mean ADC value(P=0.099).A multivariate model combining maximum diameter, CNR with b values of 800 s/mm2 and delayed phase enhancement most significantly discriminated TNBC from other three subtypes(AUC=0.84).  

In addition to the morphological features, DCE-MRI and DWI could provide novel quantitative information reflecting invasive cancers microenvironment changes, with a potential role in the differentiation of molecular subtypes and to facilitate lesion-specific targeted therapies.

In addition to the morphological features, DCE-MRI and DWI could provide novel quantitative information reflecting invasive cancers microenvironment changes, with a potential role in the differentiation of molecular subtypes and to facilitate lesion-specific targeted therapies.

Zhang, L, Chen, S, Wang, S, Song, Q, Liu, A, Breast Imaging Changes of Invasive Cancers on Dynamic Contrast-enhanced and Diffusion-weighted MR Imaging: Correlation with Molecular Subtypes.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14009126.html