Tatiana Cardoso de Mello Tucunduva MD, Abstract Co-Author: Nothing to Disclose

Giselle Guedes Mello PhD, Presenter: Nothing to Disclose

Adriana Helena Padovan Grassmann Ferreira MD, PhD, Abstract Co-Author: Nothing to Disclose

Luciano F. Chala MD, Abstract Co-Author: Nothing to Disclose

Monica M.A. Stiepcich MD, PhD, Abstract Co-Author: Nothing to Disclose

Joao Luiz Marin Casagrande MD, Abstract Co-Author: Nothing to Disclose

Andrea Maciel MD, Abstract Co-Author: Nothing to Disclose

Breast cancer in young women are not common and it is widely believed that is characterized by a relatively unfavorable prognosis and pathological features. The aim of this study is to investigate frequency, clinicopathological and imaging features of breast cancer in women younger than 40 years in a specialised breast diagnostic center.

Cases were retrospectively selected from our database of 8889 consecutive breast biopsies performed between February of 2003 and September 2013. There were 2284 (25,7%) patients under 40 years in this group. Frequency, clinicopathological and imaging features of breast cancer diagnosed in this group of women were determined.

Of 1820 malignant tumors, 212 were detected in women younger than 40 years, resulting in an overall frequency of 11,6% (212/1820) in this age group. The most common imaging presentation was irregular mass (54%), followed by mass with microcalcifications (19,7%). The most frequently histologic type was invasive ductal carcinoma (60,3%), manifesting as histological grade 1 (12%), grade 2 (46%) e grade 3 (42%), followed by in situ ductal carcinoma (28,7%). The immune profile showed 28% of HER2 overexpression cases and 23% of triple negative tumors.

In this study, the frequency of malignant breast lesions in patients under the age of 40 years was 11,6%, with a predominance of histological grade 2 and 3 ductal carcinomas and which manifests primarily as masses in imaging methods.

The study of frequency and phenotypic features of the tumors in patients younger than 40 years generates epidemiological information and comparative basis of tumor behavior in different population groups

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Tucunduva, T, Mello, G, Ferreira, A, Chala, L, Stiepcich, M, Marin Casagrande, J, Maciel, A, Breast Cancer In Women Under 40 Years: Frequency, Clinicopathologic and Imaging Features – 10 Years Of Experience.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008957.html