Guan-Min Quan MD, Presenter: Nothing to Disclose

Yang Liu, Abstract Co-Author: Nothing to Disclose

Shengyong Wu MD, PhD, Abstract Co-Author: Consultant, Qmetrics Technologies

Tao Yuan MD, Abstract Co-Author: Nothing to Disclose

To explore the value of low dose perfusion CT in guiding percutaneous lung biopsies using low-dose protocol and adaptive statistical iterative reconstruction (ASIR) technology.

A total of 120 consecutive patients who underwent CT-guided percutaneous lung biopsy were enrolled and randomised into group 1 (low dose perfusion),group 2(standard dose perfusion), group 3(contrast enhancement) and group 4(non-contrast-enhanced CT); there was no significant difference about lesion features. Positive rate of biopsy, the accuracy in classification and grading of lung cancer and the incidences of complications were recorded. Positive rate of biopsy, the accuracy in classification and grading of lung cancer and the incidences of complications,and radiation doses were compared between these groups.

The positive rate of biopsy and the accuracy in classification and grading of lung cancer were 96.7% and 100% in group 1, 93.3% and 100% in group 2, 93.3% and 83.3% in group 3, 73.3% and 75% in group 4. The differences about the positive rate of biopsy were not statistically significant between the group 1 and 3 (χ2=0.351, P=0.554), the positive rate of biopsy of group 2 was the same with that of group 3. The accuracy in classification and grading of lung cancer of group 1 was higher than that of group 3 (χ2=4.537，P=0.033). The accuracy in classification and grading of lung cancer of group 1 was the same with that of group 2. The positive rate of biopsy of group 1,2 and 3 were higher than that of group 4 (P<0.05). The incidences of total complications were 10% in group 1, 20% in group 2, 16.7% in group 3, 46.7% in group 4. The incidences of total complications of group 1,2,3 were lower than that of group 4 (P<0.05). The incidences of total complications of group1, 2 and 3 had no significant difference between each other (χ2=1.184, P=0.553). The effective dose were 4.25±0.72 mSv in group1, 9.94±1.93 mSv in group 2（t=-15.101，P=2.09×10-17）.

The application of low dose perfusion CT during lung biopsies can improve the positive rate of biopsy and the accuracy in classification and grading of lung cancer with the reduction of incidences of complications. Radiation dose during CT-guided percutaneous lung biopsies is reduced greater through the use of low dose perfusion compared with standard dose perfusion group.

 low dose CTP of squamous cell carcinomas case

Quan, G, Liu, Y, Wu, S, Yuan, T, The Preliminary Study of Perfusion CT in Guiding Percutaneous Lung Biopsies Using Low-dose Protocol and ASIR Technology.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008871.html