Min Zhang, Presenter: Nothing to Disclose

Kuncheng Li MD, Abstract Co-Author: Nothing to Disclose

chunshui yu, Abstract Co-Author: Nothing to Disclose

Wen Qin, Abstract Co-Author: Nothing to Disclose

We aimed to address the exact relationships between the evolution of diffusion indices and its underlying pathology in central nervous system.

Twenty-five domestic mature Felis catus were included in the present study. The evolution of diffusion indices, including mean diffusivity (MD),fractional anisotropy (FA),primary （入1）and transverse（入2,3） eigenvalues of the degenerated corticospinal tract,we were observed at baseline(before modeling) and at 2,4,6,8,10,15,20,25,30,45 and 60 days after modeling in 4 cats.Pathological examinations were performed at eight time points metioned above.

Wallerian degeneration can be detected as early as the 2nd day after modeling by both diffusion tensor imaging and pathology. According to the evolution of diffusion indices,Wallerian degeneration can be classified into 2 stages.During the early stage (within 8 days after modeling),progressive disintegration of axons and myelin sheaths underlies the decreases in FA and 入1 and the increase in 入2,3.However,during the late stage(after 8 days ),the gradual increase in FA,MD and 入1 and the unchanged 入23 seem to be a comprehensive reflection of the pathological processes including microglia activation,myelin clearance,and astrocytosis.

Our findings help the understanding of the altered diffusion indices in the context of pathology and suggest that diffsion tensor imaging has the potential to monitor the processes of Wallerian degeneration in the central nervous system in vivo after acute damage.

DTI  has the potential to monitor the processes of Wallerian degeneration in the central nervous system in vivo after acute damage.

Zhang, M, Li, K, yu, c, Qin, W, Dynamic Associations between Diffusion Indices and Their Underlying Pathology of Wallerian Degeneration in Central Nervous System.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008639.html