Sadia Choudhery MD, Presenter: Nothing to Disclose

Rajaa Mohammed Almestady MD, Abstract Co-Author: Nothing to Disclose

Hythem Adnan Omar MD, Abstract Co-Author: Nothing to Disclose

Yasmeen M. Butt, Abstract Co-Author: Nothing to Disclose

Suhny Abbara MD, Abstract Co-Author: Research Consultant, Radiology Consulting Group

Nagina Malguria MBBS, Abstract Co-Author: Nothing to Disclose

The objectives are to: 1) Review primary and secondary forms of cardiac amyloidosis and their pathophysiology. 2) Present spectrum of findings on multimodality imaging of amyloidosis and provide pathology correlation. 3) Discuss clinical management and role of imaging in amyloidosis.

1. Amyloidosis: Definition & types: Primary, secondary & localized. 2. Pathophysiology of amyloidosis & relavance to imaging manifestations. 3. Review of characteristic imaging & pathology features of amyloidosis in the heart & other organ systems: • Cardiac: Diffuse subendocardial enhancement, patchy myocardial enhancement, atrial enhancement, enhancement on both sides of the ventricular septum, early washin and washout of contrast on MRI. Inversion time(TI) of myocardium shorter than or equal to that of blood pool. • Extracardiac: Tracheobronchial: Diffuse thickening, nodules. Lungs: Interstitial disease, nodules. Brain: Cerebral amyloid angiopathy, lobar hemorrhages. Head and Neck :Calcified or noncalcified nodules, low intensity nodules on MRI, perineural enhancement. Renal: Large echogenic kidneys on ultrasound. Musculoskeletal system: Osseous erosions with low to intermediate T1/T2 soft tissue and intra-articular deposits with variable enhancement. 4. Role of imaging & significance of accurate diagnosis in treatment options.

http://abstract.rsna.org/uploads/2014/14008390/14008390_h2i2.pdf

Choudhery, S, Almestady, R, Omar, H, Butt, Y, Abbara, S, Malguria, N, Amyloidosis: Within the Heart and beyond.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008390.html