Hyoun Cho MD, Presenter: Nothing to Disclose

Ho Yun Lee MD, Abstract Co-Author: Nothing to Disclose

Kyung Soo Lee MD, PhD, Abstract Co-Author: Nothing to Disclose

Byung-Tae Kim MD, Abstract Co-Author: Nothing to Disclose

O. Jung Kwon, Abstract Co-Author: Nothing to Disclose

Joungho Han, Abstract Co-Author: Nothing to Disclose

Jhingook Kim, Abstract Co-Author: Nothing to Disclose

As a staging workup for pure ground glass opacity (GGO) nodular adenocarcinoma, the role of 18F-FDG PET/CT scanning or brain MRI has been questioned. The purpose of this study was to determine the value of 18F-FDG PET/CT and brain MRI for the preoperative staging of lung adenocarcinoma manifesting as pure GGO.

164 patients (M:F=73:91; mean age=62) with lung adenocarcinoma manifesting as pure GGO who underwent 18F-FDG PET/CT or brain MRI before surgery were included. Pathologic findings for nodal staging and pathologic or follow-up imaging findings for M staging were reference standards.

Among all 175 tumors, 34 were adenocarcinoma in situ (19 %), 54 were minimally invasive adenocarcinoma (31 %) and 87 were invasive adenocarcinoma (50 %). The most frequently observed histologic subtypes, in decreasing order, were lepidic (69%), acinar (26%), and papillary (5%). On PET/CT scan, abnormal FDG-uptake of lymph node was found in two of all 136 patients (1.5%), which were negative on final pathology. Abnormal FDG-uptake of liver was detected in one patient, which was also negative confirmed by dedicated abdomen CT. No brain metastasis was found in brain MRI of all 109 patients. The median follow-up time was 36.7 months, and only one patient (0.9%) developed brain metastasis after surgical resection.

18F-FDG PET/CT and brain MRI add little values in the staging of lung adenocarcinoma manifesting as pure GGO.

Lung adenocarcinoma manifesting as pure GGO do not require 18F-FDG PET/CT scan nor brain MRI for staging.

Cho, H, Lee, H, Lee, K, Kim, B, Kwon, O, Han, J, Kim, J, Staging Workup for Patients with Pure Ground Glass Nodular Adenocarcinomas: Are PET/CT and Brain MRI Mandatory?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008355.html