Jung Hoon Kim MD, Presenter: Nothing to Disclose

Ijin Joo MD, Abstract Co-Author: Nothing to Disclose

Jeong Min Lee MD, Abstract Co-Author: Research Grant, Guerbet SA Equipment support, Siemens AG Research Grant, Bayer AG

Joon Koo Han MD, Abstract Co-Author: Nothing to Disclose

Byung Ihn Choi MD, PhD, Abstract Co-Author: Research Consultant, Samsung Electronics Co Ltd

The purpose of this study is early therapeutic response evaluation after cytotoxic chemotherapy using FOLFOX and FOLFIRI in patients with liver metastasis from colorectal cancer using IVIM DWI and DCE-MRI.

This prospective study was approved by IRB and informed consent was obtained from the study patients. Nineteen patients with liver metastasis from colorectal cancer underwent DEC-MRI and IVIM DWI (b value=0, 25, 50, 75, 100, 200, 500, and 800 sec/mm2) using a 3-T MR scanner baseline and after 1st cycle of cytotoxic chemotherapy using FOLFOX and FOLFIRI. Following IVIM DWI parameters including ADC, true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) and DCE-MR perfusion parameters including Ktrans, Kep, Ve, and iAUC were calculated. Response evaluation based on RECIST criteria. For statistical analysis, Spearman's rank correlation and Wilcoxon signed-rank was applied.

There were eight response and eleven non-response patients. In the comparison of IVIM DWI parameters, ADC (1.19±0.23 vs 1.26±0.26, 10-3/mm2/s, p=.012), D (1.08±0.23 vs. 1.17±0.24, 10-3/mm2/s, p=.012), f (17.3±0.03 vs. 13.3±0.02,%, p=.017) showed significant change between baseline and after 1st cycle chemotherapy in the response group. However, in the comparison of DCE-MR perfusion parameters including Ktrans, Kep, Ve, and iAUC, there were no statistically significant change in each DCE-MR perfusion parameters. The significant correlation was found between each of the perfusion-related IVIM parameters (D* and f) with DCE-MR parameters (Ktrans and iAUC) before chemotherapy (r=0.506 to 0.614, p<0.05), however there were no significant correlation after chemotherapy.

IVIM DWI is useful for early prediction of therapeutic response evaluation after cytotoxic chemotherapy in patients with liver metastasis from colorectal cancer.

IVIM DWI of the liver metastasis from colorectal cancer can be used as early prediction of therapeutic response evaluation after cytotoxic chemotherapy

Kim, J, Joo, I, Lee, J, Han, J, Choi, B, Early Therapeutic Response Evaluation after FOLFOX and FOLFIRI Treatment in Patients with Liver Metastasis from Colorectal Cancer Using IVIM DWI and DCE-MRI.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008354.html