Cornelia Laule PhD, Presenter: Nothing to Disclose

Irene M. Vavasour PhD, Abstract Co-Author: Nothing to Disclose

Shannon H. Kolind PhD, Abstract Co-Author: Nothing to Disclose

Thorarin Albert Bjarnason PhD, Abstract Co-Author: Nothing to Disclose

Jing Zhang PhD, Abstract Co-Author: Nothing to Disclose

Donna J. Lang DPhil, DSc, Abstract Co-Author: Nothing to Disclose

Piotr Kozlowski PhD, Abstract Co-Author: Nothing to Disclose

Alexander Rauscher PhD, MSc, Abstract Co-Author: Advisory Board, F. Hoffmann-La Roche Ltd

Lara Boyd PhD, Abstract Co-Author: Nothing to Disclose

Anthony Traboulsee MD, Abstract Co-Author: Researcher, Angiotech Pharmaceuticals, Inc Researcher, Bayer AG Researcher, BioMS Medical Researcher, Johnson & Johnson Researcher, DAIICHI SANKYO Group Researcher, F. Hoffmann-La Roche Ltd Researcher, Merck KGaA Researcher, Schering-Plough Corporation Researcher, Teva Pharmaceutical Industries Ltd Researcher, sanofi-aventis Group Researcher, Transition Therapeutics Inc Consultant, sanofi-aventis Group Research Grant, F. Hoffmann-La Roche Ltd Research Grant, sanofi-aventis Group

G.R.Wayne Moore MD, Abstract Co-Author: Nothing to Disclose

David Kwok Boon Li MD, Abstract Co-Author: Researcher, sanofi-aventis Group Researcher, F. Hoffmann-La Roche Ltd Researcher, Merck KGaA Researcher, Novartis AG Researcher, Nuron Biotech, Inc Researcher, PAREXEL International Corporation Consultant, sanofi-aventis Group Consultant, F. Hoffmann-La Roche Ltd Scientific Advisory Board, Novartis AG Scientific Advisory Board, Nuron Biotech, Inc Scientific Advisory Board, Opexa Therapeutics, Inc

Alex L. MacKay PhD, Abstract Co-Author: Nothing to Disclose

The purpose of this exhibit is: 1. To explain the anatomical basis of myelin water 2. To describe the MRI acquisition and analysis of multi-echo T2-relaxation based myelin water imaging 3. To summarize key myelin water imaging findings in healthy brain and spinal cord tissue 4. To review myelin water imaging abnormalities in different central nervous system pathological conditions including multiple sclerosis, stroke, schizophrenia, concussion and phenylketonuria 5. To learn how myelin water findings compare to other advanced neuroimaging MR techniques such as diffusion tensor and magnetization transfer imaging  

1. What is the value of measuring myelin? 2. Background on myelin water imaging technique     a. Anatomical basis of myelin water     b. Data acquisition     c. Data analysis 3. Is myelin water actually related to myelin? Histological validation in preclinical models and post-mortem human tissue 4. Myelin water in healthy tissue     a. Brain     b. Spinal cord 5. Myelin water in pathological tissue     a. Multiple sclerosis     b. Stroke     c. Schizophrenia     d. Concussion     e. Phenylketonuria 6. Comparison of myelin water to other advanced neuroimaging methods 7. What is the significance and future of myelin water imaging?      

http://abstract.rsna.org/uploads/2014/14008255/14008255_hzdr.pdf

Laule, C, Vavasour, I, Kolind, S, Bjarnason, T, Zhang, J, Lang, D, Kozlowski, P, Rauscher, A, Boyd, L, Traboulsee, A, Moore, G, Li, D, MacKay, A, MRI of Myelin Water: Principles and Applications of an Emerging Technique.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14008255.html