Sudheer Balakrishnan MD, Abstract Co-Author: Nothing to Disclose

Lisa Marie Tartaglino MD, Presenter: Nothing to Disclose

Mechanism of radiation injury is likely multifactorial representing a combination of demyelination, vascular injury/ischemia as well as host immune response. Neurotoxicity can be divided into three phases: Acute, Early delayed and Late delayed Acute radiation neurotoxicity is due to disruption of the blood-brain barrier and associated vasogenic edema Early delayed neurotoxicity involves continued vasogenic edema and demyelination Late delayed neurotoxicity results from continued demyelination, white matter necrosis and ischemic vasculopathy  

1. Introduction 2. Expected changes to the brain following radiation 3. Acute encephalopathy      -White matter edema 4. Early delayed      -White matter edema +/- enhancement that spontaneously resolves 5. Late delayed      -Cerebral atrophy      -Vascular complications (ischmic vasculopathy, cavernoma)      -Radiation necrosis      -Cysts      -SMART (stroke like migraine attacks after radiation therapy) syndrome      

http://abstract.rsna.org/uploads/2014/14007952/14007952_2ouz.pdf

Balakrishnan, S, Tartaglino, L, Spectrum of Radiation Induced Changes in the Brain.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007952.html