Ann Packard MD, Presenter: Nothing to Disclose

Christopher Harker Hunt MD, Abstract Co-Author: Nothing to Disclose

Geoffrey Bates Johnson MD, PhD, Abstract Co-Author: Nothing to Disclose

Patrick James Peller MD, Abstract Co-Author: Speakers Bureau, General Electric Company

1. Review the pathophysiology of paraneoplastic syndrome of the CNS, with emphasis on how it differs from extra-neural PNS. 2. Review the typical PET/CT imaging findings of PNS including cerebellar degeneration, limbic encephalitis, and opsoclonus-myoclonus. 3. Compare PET/CT imaging of PNS with conventional MRI imaging. 4. Evaluation of PNS progression and/or response to therapy. 5. Illustrate the clinical role of whole body PET/CT for identification of causative neoplasm.  

Pathophysiology of paraneoplastic syndromes of the CNS Difference between CNS and extra-neural PNS The role of immune-mediated complexes in PNS of the CNS Review imaging of PNS Conventional imaging (MRI, CT) Molecular imaging (PET/CT) Repeat imaging for progression/response evaluation Use of FDG PET/CT to detect occult primary malignancies  

http://abstract.rsna.org/uploads/2014/14007823/14007823_kd79.pdf

Packard, A, Hunt, C, Johnson, G, Peller, P, FDG PET/CT Imaging in Paraneoplastic Syndromes Involving the Central Nervous System.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007823.html