yu xiao ping MD, Presenter: Nothing to Disclose

Li Fei Ping, Abstract Co-Author: Nothing to Disclose

Lu Qiang, Abstract Co-Author: Nothing to Disclose

To study the potential correlations between MR perfusion parameters and intravoxel incoherent motion (IVIM) parameters in nasopharyngeal carcinoma (NPC), and hence investigate the underlying clinical significance

 A total of 30 patients detected with NPC (21 men, 9 women) were enrolled in this study. Content forms were obtained from all patients prior to the study. All patients underwent dynamic contrast-enhanced T1-weighted MR perfusion and multi-b value based IVIM diffusion exams (b=0, 50, 80, 100,150,200,400,600,800, 1000 s/mm2) on a 1.5T scanner. For each primary tumor, MR perfusion parameters including Ktrans (volume transfer constant), Ve (volume fraction) , fPV (fractional plasma volume) and kep were obtained and recorded from the perfusion data. Additionally, IVIM parameters (ADCstandard, ADCslow, ADCfast, Fraction of ADCfast) were obtained from the IVIM diffusion MR maps. Pearson correlation coefficients between the two groups were obtained to evaluate the potential correlations between MR perfusion parameters and IVIM diffusion parameters.

The Ktrans ,Kep ,Ve and fPV values of NPC were 0.336±0.094/min, 1.502±0.420/min, 0.234±0.053 and 0.008 ±0.009 respectively; whereas the standardADC, slowADC,fastADC, fraction of fastADC of the corresponding NPC were (0.950±0.175) × 10-3 mm2 /s, (0.685 ±0.113)× 10-3 mm2 /s,(0.020 ± 0.018 ) × 10-3 mm2 /s and (0.315 ±0.102) × 10-3 mm2 /s respectively. Ve value revealed a significant correlation with fastADC values(r=0.450, p=0.013). Ktrans value showed a positive correlation with fastADC values(r=0.378, p=0.039). However Kep and fPV values did not show significant statistical correlation with the IVIM parameters in NPC(table 1). 

 Ktrans and fPV values of the perfusion imaging showed significant correlation with the IVIM parameters, such correlation was not seen in between other perfusion parameters and IVIM parameters. The underlying physiological mechanism is to be studied. 

 The correlations between MR perfusion parameters and intravoxel incoherent motion diffusion parameters  is helpful in understanding the relation between the two MR exams on nasopharyngeal carcinoma.

ping, y, Ping, L, Qiang, L, Correlations between Perfusion and Intravoxel Incoherent Motion (IVIM) Diffusion in Nasopharyngeal Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007804.html