Laure Delphine Boyer, Presenter: Nothing to Disclose

Stephen Randall Thomas PhD, Abstract Co-Author: Nothing to Disclose

Ingrid Leguerney, Abstract Co-Author: Nothing to Disclose

Nathalie Brigitte Lassau MD, PhD, Abstract Co-Author: Speaker, Toshiba Corporation Speaker, Bracco Group Speaker, Novartis AG Speaker, Pfizer Inc Speaker, F. Hoffmann-La Roche Ltd

Stephanie Pitre-Champagnat, Abstract Co-Author: Nothing to Disclose

NM with the Fluent software was validated to study blood and CA dynamics in simple geometries. Results obtained with realistic vascular networks composed of 25 to 137 vessels of 30 to 100µm diameter will be presented.

Dynamic Contrast-Enhanced Ultrasonography (DCE-US) is a particularly attractive method to assess tumor microvasculature from the quantification of ultrasound contrast agents (CA) within lesion. This method does not yet benefit methodological tools imported from physics to characterize the ability of the quantification methods to evaluate tumor microcirculation. In this context, we developed the first numerical modeling (NM) based on Computational Fluid Dynamics software to study the quantification methods to describe the tumor perfusion in a complex vascular network and to apprehend their variations according to tumor growth. The aim of this study was to validate this approach in comparison with DCE-US experiments on few characteristical geometries configurations and to extend to more realistic geometries of vascular network.

NM was performed with Fluent software (ANSYS, France), which modeled blood and CA flows in vascular network with laminar flow described by Poiseuille's law. Three geometries of numerical and experimental phantoms were a 2mm diameter tube representing respectively a single vessel, a bifurcation towards 2 parallel tubes and a serpentine. Volume of injected CA was 0.1mL with a blood flow of 41mL/min. Realistic injection of CA by bolus was implemented in NM. DCE-US experiments were performed with an Aplio scanner (Toshiba, Japan) and a 12MHz probe with SonoVue® (Bracco, Italy) as CA.

Numerical time-concentration of CA curves were similar to those obtained experimentally for the three geometries.

Boyer, L, Thomas, S, Leguerney, I, Lassau, N, Pitre-Champagnat, S, Numerical Modeling of the Dynamic of Ultrasound Contrast Agents in Vascular Network.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007764.html