Meng Lin, Presenter: Nothing to Disclose

Xiaoduo Yu, Abstract Co-Author: Nothing to Disclose

Lin Li MD, Abstract Co-Author: Nothing to Disclose

Dehong Luo MD, Abstract Co-Author: Nothing to Disclose

Chun-Wu Zhou MD, Abstract Co-Author: Nothing to Disclose

ZHENYU ZHOU, Abstract Co-Author: Nothing to Disclose

To evaluate the use of pretreatment semi-quantitative and quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in predicting sensitivity of concurrent chemoradiation in nasopharyngeal carcinoma.

36 patients with nasopharyngeal carcinoma proved by nasopharyngoscope and biopsy pathology (from January to December 2013) underwent DCE-MRI exams before concurrent chemoradiation. Semi-quantitative and quantitative parameters of the mean (delineation of maximum area of tumor) and hot area (depicted on Ktrans map) were processed by GenIQ software (GE) including MaxSlop, CER, IAUGC, Ktrans, Kep and Ve. The patients were re-examined MRI during treatment (with dose of 50Gy) and after treatment (at the end of conventional treatment). According to the tumor regression rate after treatment, the patients were classified into group complete response (CR) and group non-CR including partial response (PR) and stable disease (SD). The correlations between pretreatment parameters and tumor regression rate were analyzed. Parameters between group CR and non-CR were compared by independent T-test. The value of parameters on predicting CR were assessed by ROC.

Tumor regression rate during and after treatment showed positive correlation with tumor mean and hot area IAUGC, Ktrans, Kep, mean Maxslop and hot area CER (r: 0.341 ~ 0.608, P: ＜0.001 ~ 0.042). Tumor mean CER demonstrated positive correlation to tumor regression rate after treatment (r=0.350，P=0.036). Statistical differences were existed between group CR and non-CR in tumor hot area CER (1.802±0.297 VS. 1.567±0.293), IAUGC (0.236±0.040 VS. 0.193±0.031), mean Ktrans (0.178±0.033 min-1 VS. 0.136±0.033 min-1), hot area Ktrans (0.228±0.042 min-1 VS. 0.177±0.031 min-1) and mean Kep (1.246±0.313 min-1 VS. 0.925±0.228 min-1) (P: <0.001 ~ 0.024). ROC indicated that when setting threshold of Kep on more than or equal to 1.11 min-1 for predicting CR after treatment, the specificity, sensitivity and accuracy were 71.4%, 86.7% and 77.8% respectively, with area under curve of 0.832 (P=0.001).

Pretreatment semiquantitative and quantitative DCE-MRI were capable of predicting sensitivity of concurrent chemoradiation in nasopharyngeal carcinoma.

Pretreatment semi-quantitative and quantitative parameters of DCE-MRI  has potential to be helpful in individualized therapy.

Lin, M, Yu, X, Li, L, Luo, D, Zhou, C, ZHOU, Z, Use of Pretreatment Semiquantitative and Quantitative Dynamic Contrast-enhanced Magnetic Resonance Imaging in Predicting Sensitivity of Concurrent Chemoradiation in Nasopharyngeal Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007585.html