Meng Lin, Presenter: Nothing to Disclose

Xiaoduo Yu, Abstract Co-Author: Nothing to Disclose

Dehong Luo MD, Abstract Co-Author: Nothing to Disclose

Han Ouyang MD, Abstract Co-Author: Nothing to Disclose

Chun-Wu Zhou MD, Abstract Co-Author: Nothing to Disclose

ZHENYU ZHOU, Abstract Co-Author: Nothing to Disclose

To invesitgate the use of pre-treatment diffusion-weighted imaging（DWI）in predicting therapeutic effect of concurrent chemoradiation in nasopharyngeal carcinoma.

65 patients with nasopharyngeal carcinoma confirmed by nasopharyngoscope and biopsy pathology (from October 2009 to December 2012) underwent DWI (b value=0, 800 s／mm2) before concurrent chemoradiation, during treatment (with dose of 50Gy) and after treatment (at the end of conventional treatment) using a 3.0T MR. The mean, maximum and minimum ADC value of tumor as well as the delineation of maximum area of tumor in pretreatment, during and after treatment were recorded to estimate the tumor regression rate. The subjects were put into two categories according to the tumor regression rate after treatment: group of complete response (CR) and group of non-CR including partial response (PR) and stable disease (SD). Spearman’s correlation analysis was applied between the ADC values and tumor regression rates. Independent T-test was also used to compare the ADC values of group CR and group non-CR. Moreover, ROC analysis was applied for the evaluation of ADC values in predicting group CR.

The mean and maximum ADC were found to have negative correlation with tumor regression rate during and after treatment (r: -0.463 - -0.552, P＜0.001). There were statistical differences between group CR and non-CR for mean ADC (0.98±0.12×10-3mm2/s VS. 1.14±0.13×10-3mm2/s) and for maximum ADC (1.16±0.21±0.13×10-3mm2/s VS. 1.42±0.23×10-3mm2/s), both with P value less than 0.001. ROC curve indicated that using a threshold of mean ADC value lower than 1.09×10-3mm2/s on predicting group CR led to specificity, sensitivity, and accuracy of 82.5%, 76.0% and 80.0% respectively, with area under curve of 0.816 (P＜0.001).

Quantitative DWI measurement (ADC) was shown to be capable of predicting therapeutic effect of concurrent chemoradiation in nasopharyngeal carcinoma.

Pretreatment DWI possessed potential to be applied in individualized therapy, according to its capability of predicting therapeutic effect of concurrent chemoradiation in nasopharyngeal carcinoma.

Lin, M, Yu, X, Luo, D, Ouyang, H, Zhou, C, ZHOU, Z, Prediction of Therapeutic Effect of Concurrent Chemoradiation in Nasopharyngeal Carcinoma Based on Pretreatment Quantitative Diffusion-weighted Imaging.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007563.html