Tatiana Kelil MD, Presenter: Nothing to Disclose

Stephanie A. Howard MD, Abstract Co-Author: Nothing to Disclose

Michael Hayden Rosenthal MD, PhD, Abstract Co-Author: Nothing to Disclose

Katherine Margaret Krajewski MD, Abstract Co-Author: Research Grant, General Electric Company Spouse, Employee, Ironwood Pharmaceuticals, Inc

Nikhil H. Ramaiya MD, Abstract Co-Author: Nothing to Disclose

Sreeharsha Tirumani MBBS, MD, Abstract Co-Author: Nothing to Disclose

1. Epithelial thyroid malignancies are of follicular cell (follicular (FTC), papillary (PTC), Hurthle cell, anaplastic thyroid carcinoma) or c-cell (medullary thyroid carcinoma (MTC)) origin. 2. PTC is associated with mutations in the APC gene (Familial Adenomatous Polyposis), familial non-MTC, Carney syndrome and childhood radiation. 3. FTC is associated with mutations in the PTEN gene (PTEN-hamartoma). 4. MTC is associated with RET gene mutations (multiple endocrine neoplasia 2A/B and familial MTC). 5. Imaging plays a crucial role in early detection and accurate staging of thyroid cancer, and in detecting other syndrome-associated tumors. 6. Correlation with biochemical markers can help radiologists in interpreting images. 7. Prognostic factors in thyroid malignancies include anaplastic histology, tumor size, familial PTC; RET mutation in sporadic MTC and vascular invasion.

1. Describe WHO classification of thyroid malignancies. 2. Review molecular genetics of thyroid malignancies with emphasis on syndromes associated with them 3. Illustrate the role of multimodality imaging (CT, MRI, PET/CT) in staging, evaluating treatment response and post treatment surveillance. 4. Elucidate advances in imaging techniques including new radiotracers 5. Discuss advances in treatment including molecular targeted therapies.

http://abstract.rsna.org/uploads/2014/14007492/14007492_giou.pdf

Kelil, T, Howard, S, Rosenthal, M, Krajewski, K, Ramaiya, N, Tirumani, S, Current Concepts in Molecular Genetics and Management of Thyroid Malignancies: An Update for Radiologists.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007492.html