Tatiana Kelil MD, Presenter: Nothing to Disclose

Sreeharsha Tirumani MBBS, MD, Abstract Co-Author: Nothing to Disclose

Michael Hayden Rosenthal MD, PhD, Abstract Co-Author: Nothing to Disclose

Nikhil H. Ramaiya MD, Abstract Co-Author: Nothing to Disclose

Monica J. Wood BS, Abstract Co-Author: Nothing to Disclose

Stephanie A. Howard MD, Abstract Co-Author: Nothing to Disclose

1. The revised 2010 WHO classification of neuroendocrine tumors (NET) classifies small cell carcinoma (SCC) as grade 3 neuroendocrine carcinoma based on mitotic count and proliferation index. 2. SCC most commonly occurs in the lung and uncommonly in extrapulmonary sites (2-5%). 3. Extrapulmonary SCC most commonly occurs in GI (particularly esophagus) and GU (particularly cervix and bladder) tracts. 4. SCC is characterized by mutations in p53, loss of retinoblastoma gene (RB1) and telomerase function and activation of c-KIT, MYC and PARP1. 5. SCC of the lung has striking early response to chemoradiation with high relapse rates and unusual metastasis. 6. Relapsed SCC is extremely difficult to treat, though some respond to temozolamide, particularly in the setting of brain metastases. 7. Novel molecular targeted therapies (MTTs) in SCC include Aurora kinase (MYC) and PARP inhibitors.

1. Revised 2010 WHO classification of NET, focusing on pulmonary and extrapulmonary SCC. 2. Risk factors and epidemiology of SCC. 3. Role of multimodality imaging (CT, MRI, PET/CT) in disease staging, focusing on prognostic implications of disease site 4. Illustrate typical and atypical metastases evaluating for recurrent disease. 5. Future directions of treatment, including role of temozolomide and novel MTTs.

http://abstract.rsna.org/uploads/2014/14007482/14007482_5yxr.pdf

Kelil, T, Tirumani, S, Rosenthal, M, Ramaiya, N, Wood, M, Howard, S, Blast from the Past: Multimodality Imaging of Small Cell Carcinoma from Head to Toe.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007482.html