Jinchun Yan MD, PhD, Presenter: Nothing to Disclose

Jason Sun MD, Abstract Co-Author: Nothing to Disclose

Fatemeh Behnia MD, Abstract Co-Author: Nothing to Disclose

Manuela Cristina Matesan MD, PhD, Abstract Co-Author: Nothing to Disclose

Stephen R. Bowen PhD, Abstract Co-Author: Nothing to Disclose

Shilpen Ajit Patel MD, Abstract Co-Author: Nothing to Disclose

Jing Zeng MD, Abstract Co-Author: Nothing to Disclose

1. A comprehensive understanding of the time course of radiation induced lung changes and their imaging is important in the diagnosis and management of patients who have received radiation therapy. 2. A comprehensive understanding of the biology of radiation pneumonitis and its relationship with FDG PET-CT imaging and In111-Pentetreotide SPECT-CT imaging.  

Radiation-induced lung changes are common among patients treated with radiotherapy. Imaging manifestations usually are confined to the radiation field and dependent on the time interval from the treatment. In the acute to subacute phase (up to 6 months), post-radiation changes typically manifest as fine ground-glass opacity or consolidation; long term, it typically manifests as fibrosis or scarring. The use of oblique beam angles and modern radiation planning that frequently utilizes multiple beam pathways can result in an unusual distribution of these findings. As presented here, FDG-PET-CT imaging showed initial intense FDG uptake in bilateral lung apices, consistent with active inflammation post-treatment, which diminished gradually by 6-months, and resolved by 2-years post-treatment at the fibrosis phase. On the other hand, 111In-Pentetreotide (Octreoscan) SPECT-CT imaging showed relatively stable uptake in bilateral lung apices post-radiotherapy.

http://abstract.rsna.org/uploads/2014/14007424/14007424_3ys9.pdf

Yan, J, Sun, J, Behnia, F, Matesan, M, Bowen, S, Patel, S, Zeng, J, FDG PET-CT and In-111 Pentetreotide SPECT-CT Imaging of Radiation Pneumonitis.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007424.html