Yan Shan, Presenter: Nothing to Disclose

Jiang Lin MD, PhD, Abstract Co-Author: Nothing to Disclose

Pengju Xu, Abstract Co-Author: Nothing to Disclose

Mengsu Zeng MD, PhD, Abstract Co-Author: Nothing to Disclose

To assess the possible association of aortic compliance and endothelial function with cerebral small vessel disease in type 2 diabetes mellitus(DM2) patients by using 3.0T high resolution magnetic resonance imaging.  

Sixty two DM2 patients (25 women and 37 men, mean age: 56.84±7.46 years) were prospectively enrolled for noninvasive MR examinations of the aorta, brachial artery, and brain. Aortic distensibility(AD), aortic arch pulse wave velocity (PWV), flow-mediated dilation(FMD) of brachial artery, lacunar brain infarcts, and periventricular and deep white matter hyperintensities (WMHs) were assessed. Pearson and Spearman correlation analysis were performed to analyze the association of aortic arch PWV, AD and FMD with clinical data and biochemical test results. Univariable logistic regression analyses were used to analyze the association of aortic arch PWV, AD and FMD with cerebral small vessel disease. Multiple logistic regression analyses were used to find out the independent predictive factors of cerebral small vessel disease.

Mean aortic arch PWV was 6.73±2.00 m/s, ascending aorta AD (AA-AD) was 2.64±1.49 ×10-3 mm Hg-1, proximal thoracic descending aorta AD (PDA-AD) was 3.08±1.25 ×10-3 mm Hg-1, distal descending aorta AD (DDA-AD) was 3.69±1.87 ×10-3 mm Hg-1, FMD was 16.67±9.11%. After adjustment for age, sex, smoke situation, diabetes duration and hypertension, PWV was statistically significantly associated with lacunar brain infarcts (OR=2.00, 95%CI: 1.14-3.2, p<0.05) and FMD was statistically significantly associated with periventricular white matter hyperintensities(OR=0.82, 95%CI: 0.71-0.95, p<0.05).

Quantitative evaluation of aortic compliance and endothelial function by using 3.0 T high-resolution MRI may contribute to stratify the cardiovascular risk factors of DM2 patients with a potential risk of cerebral small vessel disease.

Our results suggested that high-resolution MRI may help stratify cardiovascular risks in DM2 patient with direct quantification of both aortic stiffness and endothelial dysfunction.

Shan, Y, Lin, J, Xu, P, Zeng, M, Association of Aortic Compliance and Brachial Endothelial Function with Cerebral Small Vessel Disease in Type 2 Diabetes Mellitus Patients: Assessment with 3.0T MRI.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007195.html