Chuanmiao Xie MD, PhD, Abstract Co-Author: Nothing to Disclose

Zhijun Geng MD, PhD, Presenter: Nothing to Disclose

Kangqiang Peng, Abstract Co-Author: Nothing to Disclose

Zhimin Jiang, Abstract Co-Author: Nothing to Disclose

Quantitative dynamic contrast enhanced MRI (DCE-MRI) can offer information related to tumor perfusion and permeability (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve), and distribution volume (DV). The purpose of this article is to explore the feasibility and diagnostic value of quantitative DCE-MRI with liver-specific contrast agent_ Gd-EOB-DTPA in VX2 rabbit liver tumor model.

Sixteen rabbits (Body weight=3Kg, random gender) were transplanted the VX2 tumor cell. Fourteen days after tumor transplantation, all the rabbits underwent a liver DCE-MR scan in a 3.0 T MAGNETOM Verio MR scanner (Siemens Healthcare, AD, Germany) with the administration of Gadoxetic acid, disodium at the flow rate of 1mL/s, every rabbit received 0.6 mL GBCA (0.1mmol/Kg) in the DCE-MR procedure. Ktrans, Kep, Ve and DV were measured in the tumor lesion and the normal liver tissue in the same slice. A pathologic examination was also done.

Hepatocellular carcinoma was diagnosed in sixteen rabbits by pathologic examination. The Ktrans ,Kep, Ve and DV of liver tumor lesion are 0.119±0.011, 5.670±0.036, 0.101±0.033, 0.389±0.043. And the results of normal area is 0.022±0.006, 2.827±0.235, 0.045±0.007, 0.932±0.168. The Ktrans and Kep of liver tumor lesion were significant higher than the normal area (p<0.001). And the DV of liver tumor lesion was lower than the normal area (p<0.005).

In VX2 rabbit liver tumor model, quantitative DCE-MR imaging with Gadoxetic acid, disodium can develop precise quantitative result (Ktrans, Kep, Ve and Vd) for diagnosis. There is important clinical value of quantitative DCE-MR imaging in liver disease diagnosis and differential diagnosis.

Gadoxetic acid, disodium is a liver-specific gadolinium based contrast agent can be uptaken by hepatocytes and excreted by bile duct. The Kep  and Ve are different from the non-specific gadolinium based contrast agent due to the difference of excretion pathway between the two kinds of contrast agent. Hence, we must be careful when we analyze the quantitative DCE-MR data. 

Xie, C, Geng, Z, Peng, K, Jiang, Z, Study of Quantitative Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) with Liver-specific Contrast Agent—Gd-EOB-DTPA in a VX2 Rabbit Liver Tumor Model.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007098.html