Sung Yoon Park, Presenter: Nothing to Disclose

Young Taik Oh MD, Abstract Co-Author: Nothing to Disclose

Dae Chul Jung, Abstract Co-Author: Nothing to Disclose

To retrospectively analyze computed tomography (CT) characteristics of adrenal adenomas with cortisol hypersecretion by using adrenal CT compared to adenomas with aldosterone hypersecretion or non-function

Between 2011 and 2013, thirty three surgically confirmed adrenal adenomas were evaluated with adrenal CT. They were divided into group A (cortisol hypersecretion, n= 15) and group B (aldosterone hypersecretion, n= 17; non-function, n= 1). In adenomas, the lesion size, attenuation values, and absolute and relative washout rates were assessed. In the contralateral adrenal gland, the thickness of lateral and medial limbs, and body was measured and averaged. Quantitatively, CT parameters of adenomas and contralateral adrenal thickness were compared between two groups. Qualitatively, two radiologists predicted group A with 5-point scale based on CT findings of the contralateral adrenal atropy in consensus. The student t-test and receiver operating characteristic (ROC) curve analysis were conducted

All of subjects satisfied absolute (≥ 60%) or relative (≥ 40%) washout criteria for diagnosing adenoma on adrenal CT. The contralateral adrenal thickness was 1.6 ± 0.3mm in group A and 2.6 ± 0.5mm in group B (p< 0.001). The area under the curve of the contralateral adrenal thickness was 0.939, and sensitivity and specificity with a cut-off of 2.0mm or less in thickness were 93.3% and 88.9%, respectively, for predicting group A. In qualitative analysis, 30 of 33 adenomas were correctly differentiated between two groups (overall accuracy, 90.9%)

Findings of the contralateral adrenal atropy on CT may help predict adrenal adenomas with cortisol hypersecretion

Current laboratory tests for characterizing functioning adrenal adenomas are costly and often need hospitalization. Our results suggest CT evaluation could help differentiate adenomas with cortisol hypersecretion from other types of adenomas, which information may allow clinicians to plan optimal diagnostic and therapeutic strategies

Park, S, Oh, Y, Jung, D, Prediction of Adrenal Adenomas with Cortisol Hypersecretion by Using Adrenal Computed Tomography: Emphasis on Contralateral Adrenal Atropy  .  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14007026.html